{"id":"W4322769430","doi":"10.1158/1538-7445.sabcs22-p3-07-10","title":"Abstract P3-07-10: CCTG IND.236: A Phase 1b trial of combined CFI-402257 and weekly paclitaxel in patients with HER2-negative (HER2-) advanced breast cancer (aBC)","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; BC Cancer Agency; Princess Margaret Cancer Centre; Queen's University; Spinal Cord Injury BC; University Health Network","funders":"","keywords":"Paclitaxel; Taxane; Breast cancer; Medicine; Internal medicine; Cancer; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000682313,0.001000116,0.001151635,0.00041751,0.000435223,0.0007764776,0.0009029364,0.001242446,0.01673221],"category_scores_gemma":[0.0004083682,0.0003982387,0.0004892796,0.000442084,0.0004356748,0.0003141578,0.0003104125,0.002983259,0.00265401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284313,"about_ca_system_score_gemma":0.002451843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004359337,"about_ca_topic_score_gemma":0.01586529,"domain_scores_codex":[0.9997448,0.00008147393,0.00001127878,0.00003691154,0.00004907051,0.00007629878],"domain_scores_gemma":[0.9996536,0.00003694431,0.00004299136,0.00001229772,0.00002596852,0.0002281833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4638541,0.03334483,0.0115965,0.002118869,0.00083592,0.001226341,0.0002526405,0.00259152,0.1342091,0.0007956837,0.1299837,0.2191908],"study_design_scores_gemma":[0.6839605,0.231586,0.03792011,0.0002133654,0.0005700086,0.00136696,0.00006894332,0.002073638,0.01313663,0.0002944131,0.02873648,0.0000729387],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397475,0.007494424,0.0005788321,0.004163214,0.0004850356,0.006964053,0.01220885,0.0004882187,0.02786975],"genre_scores_gemma":[0.9284841,0.004751286,0.002214219,0.003871269,0.0004622597,0.004635759,0.02170949,0.0001392661,0.03373241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01673221,"threshold_uncertainty_score":0.05597484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0716905380113208,"score_gpt":0.4652842693840806,"score_spread":0.3935937313727598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}