{"id":"W4322769656","doi":"10.1158/1538-7445.sabcs22-p5-02-22","title":"Abstract P5-02-22: Circulating Tumor DNA Genotyping of Intrinsic and Acquired Gene Alterations in Patients With Advanced Breast Cancer Receiving the Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib: Biomarker Results from POLARIS","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Palbociclib; Breast cancer; Biomarker; Oncology; Medicine; Internal medicine; Cancer; CDKN2A; Cancer research; Biology; Metastatic breast cancer; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004883208,0.0003009022,0.000312136,0.0006156535,0.0002853198,0.0006821069,0.0003474847,0.0002971749,0.001970142],"category_scores_gemma":[0.0009653125,0.0001567549,0.0001751938,0.0008560218,0.0002235843,0.0001729628,0.0002983957,0.0003289836,0.0005799996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009092678,"about_ca_system_score_gemma":0.0008103475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01377897,"about_ca_topic_score_gemma":0.01550413,"domain_scores_codex":[0.9996375,0.0000634714,0.00002341668,0.0001305067,0.0001045698,0.00004042819],"domain_scores_gemma":[0.9992535,0.0001060697,0.0001867706,0.00004942889,0.0002476763,0.0001565401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004292059,0.0001359612,0.9779602,0.00005111032,0.00009810051,0.0001548755,0.00006593888,0.0001619463,0.004890444,0.00004738107,0.002354359,0.00978755],"study_design_scores_gemma":[0.0005891866,0.001101769,0.9901673,0.00001566041,0.0001084592,0.0006231642,0.000143974,0.000561267,0.002977558,0.00003681842,0.003665873,0.000008936823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901081,0.0004725654,0.0002181311,0.0001234419,0.00001601109,0.0000655792,0.007467393,0.00002498228,0.00150366],"genre_scores_gemma":[0.9847734,0.0002043179,0.000337307,0.0001264046,0.00003112715,0.00004321272,0.01354413,0.000008628881,0.0009315113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01377897,"threshold_uncertainty_score":0.02739757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03956129808422907,"score_gpt":0.3476826222176337,"score_spread":0.3081213241334047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}