{"id":"W4322771857","doi":"10.1158/1538-7445.sabcs22-p2-24-04","title":"Abstract P2-24-04: The ER antagonist giredestrant induces profound chromatin remodeling including activation of cis-regulatory elements bound by FOXA1 and GATA3 in HR+ breast cancer models","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Chromatin; FOXA1; Transcriptome; Cancer research; Gene silencing; Breast cancer; Biology; Fulvestrant; Small interfering RNA; Chromatin immunoprecipitation; Chromatin remodeling; In vivo; Chemistry; Cell biology; Cancer; Estrogen receptor; Gene; Gene expression; RNA; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132188,0.0002929854,0.0003418599,0.0001805172,0.0001512883,0.0002548791,0.0002018567,0.0002658293,0.004928099],"category_scores_gemma":[0.00008109104,0.0001304725,0.000372716,0.0001364735,0.0002707521,0.0001372842,0.0001469184,0.0009352504,0.0009136547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011583,"about_ca_system_score_gemma":0.0002440615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007602543,"about_ca_topic_score_gemma":0.001307117,"domain_scores_codex":[0.9998642,0.00001699499,0.00001030997,0.00003866505,0.00004017884,0.00002964205],"domain_scores_gemma":[0.9999292,0.00001187551,0.00001299117,0.0000123731,0.000008037961,0.00002561082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005034607,0.00005989721,0.0001283568,0.00004529889,0.00001086075,0.00003672354,0.00001132683,0.0001129979,0.996968,0.00005333835,0.0002845329,0.001785353],"study_design_scores_gemma":[0.00004470423,0.001011016,0.002834041,0.000004962553,0.00001757947,0.0001785899,0.00003438026,0.0004088827,0.990392,0.00003420947,0.005034078,0.000005523166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850765,0.001390631,0.003014065,0.0002276473,0.0001261421,0.00009852763,0.005392042,0.0002827708,0.004391628],"genre_scores_gemma":[0.9762127,0.0009483001,0.002884947,0.0003149967,0.00002231288,0.0001402282,0.008048717,0.00009835819,0.01132932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004928099,"threshold_uncertainty_score":0.01648617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06995242485404893,"score_gpt":0.3818827093526198,"score_spread":0.3119302844985709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}