{"id":"W4322771950","doi":"10.1158/1538-7445.sabcs22-ot2-03-02","title":"Abstract OT2-03-02: lidERA Breast Cancer: A phase III adjuvant study of giredestrant (GDC-9545) vs physician’s choice of endocrine therapy in patients with estrogen receptor+, HER2– early breast cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Breast cancer; Endocrine system; Cancer; Adjuvant; Oncology; Internal medicine; Estrogen; Estrogen receptor; Gynecology; Hormone","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001738495,0.001597941,0.002144443,0.0005127323,0.0003483412,0.001254957,0.001164107,0.001561929,0.009150065],"category_scores_gemma":[0.001190608,0.0006635145,0.001884919,0.0004562109,0.001261065,0.0009675153,0.0004009052,0.004702819,0.001742474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009883549,"about_ca_system_score_gemma":0.00172637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001726081,"about_ca_topic_score_gemma":0.003661379,"domain_scores_codex":[0.9995479,0.0002188416,0.0000169597,0.00007517072,0.00003784063,0.0001032674],"domain_scores_gemma":[0.9992254,0.0001415076,0.0001197541,0.00006388585,0.0000480096,0.000401509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9000565,0.06042774,0.001157857,0.0005996989,0.0007662118,0.00005472091,0.0000965416,0.001176222,0.006431974,0.0001939076,0.002434395,0.02660418],"study_design_scores_gemma":[0.7306738,0.2639293,0.002139453,0.00002749916,0.0003196588,0.00004460895,0.00003943403,0.0008351462,0.0006784509,0.0001451635,0.001150016,0.00001741713],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845335,0.002048572,0.0005744487,0.0006909767,0.0004104097,0.005902977,0.002092133,0.0002077064,0.003539284],"genre_scores_gemma":[0.9753627,0.002235875,0.002179454,0.001718125,0.000420582,0.007384391,0.003064224,0.00006046145,0.007574242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009150065,"threshold_uncertainty_score":0.03060997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213120514381198,"score_gpt":0.3569061772716898,"score_spread":0.3347749721278778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}