{"id":"W4322771976","doi":"10.1158/1538-7445.sabcs22-her2-17","title":"Abstract HER2-17: HER2-17 Novel Quantitative HER2 Assay for Determining Dynamic HER2 Expression in the HER2 IHC 0 “Ultra-Low” Setting: Implications for Precision Therapy in HER2- Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"","keywords":"Immunohistochemistry; Medicine; Breast cancer; Trastuzumab; Cancer; Oncology; Internal medicine; HER2/neu; Metastatic breast cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001853772,0.0003192731,0.0003015945,0.0002134338,0.0004939306,0.0001100402,0.0007482178,0.0003307438,0.00001798739],"category_scores_gemma":[0.0002316668,0.0002576667,0.0001677754,0.0008214804,0.0002313828,0.00003086878,0.0001434428,0.0004868499,0.000003256732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002504898,"about_ca_system_score_gemma":0.0003674621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005434942,"about_ca_topic_score_gemma":0.00329504,"domain_scores_codex":[0.9970842,0.0001763544,0.0005243245,0.0009754176,0.0003471117,0.0008925658],"domain_scores_gemma":[0.9977791,0.0006109975,0.0001966687,0.0008158849,0.0004845246,0.000112791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003952409,0.0002333061,0.001123836,0.00007611411,0.0000245657,0.000001572267,0.0004497245,0.0007711626,0.941819,0.00007937998,0.007806828,0.04721927],"study_design_scores_gemma":[0.00548758,0.001398797,0.1926993,0.002150175,0.00003046324,0.00003745033,0.004979935,0.006070968,0.6527132,0.005825952,0.1268399,0.00176629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627481,0.0009962361,0.01824108,0.01067286,0.0001254224,0.004990845,0.001866677,0.0001118351,0.0002470188],"genre_scores_gemma":[0.9817571,0.002769823,0.006518836,0.0003158182,0.0002235141,0.007265248,0.0005073585,0.0001087564,0.000533546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2891058,"threshold_uncertainty_score":0.9999875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08948907469710293,"score_gpt":0.4771032034996924,"score_spread":0.3876141288025895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}