{"id":"W4322771976","doi":"10.1158/1538-7445.sabcs22-her2-17","title":"Abstract HER2-17: HER2-17 Novel Quantitative HER2 Assay for Determining Dynamic HER2 Expression in the HER2 IHC 0 “Ultra-Low” Setting: Implications for Precision Therapy in HER2- Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"","keywords":"Immunohistochemistry; Medicine; Breast cancer; Trastuzumab; Cancer; Oncology; Internal medicine; HER2/neu; Metastatic breast cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001877634,0.0006471497,0.0004135293,0.0008971701,0.0001940312,0.0009212405,0.0006116311,0.0005014808,0.005326218],"category_scores_gemma":[0.001490142,0.0003361774,0.0003047647,0.0005699359,0.0003548016,0.0004559085,0.0003949374,0.00101545,0.001231045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006708024,"about_ca_system_score_gemma":0.0003942309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005281448,"about_ca_topic_score_gemma":0.001092865,"domain_scores_codex":[0.99848,0.0004981061,0.00007662943,0.0003001589,0.0005658937,0.00007918906],"domain_scores_gemma":[0.9991869,0.0002297381,0.0002211672,0.00008176229,0.0002112807,0.00006906901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00156071,0.0003296422,0.03191967,0.0003166207,0.0001653832,0.0001050288,0.00006363812,0.001335352,0.9130392,0.0008391868,0.0037576,0.04656802],"study_design_scores_gemma":[0.0001794951,0.001924869,0.0502151,0.00006921063,0.0001678573,0.001631364,0.00008766434,0.01693524,0.9135771,0.000816332,0.01433122,0.00006459624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7916633,0.0129485,0.1628772,0.001358185,0.0004131441,0.0007445897,0.007887934,0.003026379,0.01908072],"genre_scores_gemma":[0.8900151,0.001685791,0.08473238,0.00161324,0.0001492926,0.0005696353,0.005208413,0.0002237247,0.01580247],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.005326218,"threshold_uncertainty_score":0.01781797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08948907469710293,"score_gpt":0.4771032034996924,"score_spread":0.3876141288025895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}