{"id":"W4322772011","doi":"10.1158/1538-7445.sabcs22-ot2-16-02","title":"Abstract OT2-16-02: Open-label, phase 3b/4 study of trastuzumab deruxtecan (T-DXd) in patients with or without baseline brain metastasis with advanced/metastatic human epidermal growth factor receptor 2–positive breast cancer: DESTINY-Breast12","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Internal medicine; Oncology; Trastuzumab; Brain metastasis; Metastatic breast cancer; Population; Phases of clinical research; Cancer; Breast cancer; Clinical trial; Metastasis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001507016,0.002059975,0.001994959,0.0004827314,0.0004043211,0.001621206,0.001071072,0.001345388,0.007324252],"category_scores_gemma":[0.0007596604,0.0007330271,0.001424359,0.0005756741,0.001015139,0.0009860956,0.0003598721,0.003251794,0.002029878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001166341,"about_ca_system_score_gemma":0.001561464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002072423,"about_ca_topic_score_gemma":0.005128602,"domain_scores_codex":[0.9996586,0.0001500636,0.000015649,0.00005640518,0.00003389784,0.00008552326],"domain_scores_gemma":[0.9995266,0.00005144964,0.00007593727,0.00004519825,0.00003642957,0.000264364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7996287,0.06592716,0.003444937,0.001174576,0.001518167,0.0002586597,0.0002999553,0.001886245,0.04356815,0.0003465631,0.004752938,0.07719386],"study_design_scores_gemma":[0.7488624,0.2382681,0.006240328,0.00003848113,0.0003743078,0.000194718,0.00006742522,0.000820888,0.002185976,0.0001756425,0.002742166,0.00002966318],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986343,0.002592952,0.0006607921,0.000548028,0.0002105101,0.003124458,0.003368952,0.000194076,0.0029573],"genre_scores_gemma":[0.9713912,0.003240482,0.001968698,0.001294077,0.0002502918,0.003579447,0.006678673,0.00009532287,0.01150188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007324252,"threshold_uncertainty_score":0.02450204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1270760135590004,"score_gpt":0.4622640163961902,"score_spread":0.3351880028371899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}