{"id":"W4322772055","doi":"10.1158/1538-7445.sabcs22-ot1-03-05","title":"Abstract OT1-03-05: TROPION-Breast02: Phase 3, open-label, randomized study of first-line datopotamab deruxtecan versus chemotherapy in patients with locally recurrent inoperable or metastatic TNBC who are not candidates for anti-PD-(L)1 therapy","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Oncology; Phases of clinical research; Metastatic breast cancer; Neutropenia; Chemotherapy; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002748697,0.0004381086,0.001981892,0.0007952006,0.0003303411,0.0001389609,0.0007715198,0.00007876279,0.0003279936],"category_scores_gemma":[0.001275862,0.0002736413,0.00008888442,0.002230853,0.0005091915,0.0002837525,0.0003126168,0.0007133142,0.00001138399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008561955,"about_ca_system_score_gemma":0.001400471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006436379,"about_ca_topic_score_gemma":0.01148966,"domain_scores_codex":[0.994611,0.0005066231,0.0008583984,0.0009388974,0.001867285,0.001217858],"domain_scores_gemma":[0.9949116,0.002032749,0.0002658464,0.0008222309,0.001652318,0.0003152854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9260356,0.00984041,0.01807643,0.001117676,0.00229701,0.0001387471,0.003458691,0.0001258194,0.0004104289,0.000006082391,0.005608897,0.03288424],"study_design_scores_gemma":[0.9449854,0.02082995,0.02222211,0.001818785,0.0001362897,0.000001116778,0.003109112,0.0009415801,0.003580743,0.00002644471,0.001951873,0.0003965317],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790996,0.00113706,0.00001560617,0.002775923,0.0001756715,0.01624881,0.0004560092,0.00005269488,0.00003865052],"genre_scores_gemma":[0.9844224,0.007780475,0.00009565318,0.0000941119,0.0001092269,0.006768797,0.0001601767,0.0001201177,0.0004490697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03248771,"threshold_uncertainty_score":0.9999716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1828731618975911,"score_gpt":0.4921451045105572,"score_spread":0.3092719426129661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}