{"id":"W4322772055","doi":"10.1158/1538-7445.sabcs22-ot1-03-05","title":"Abstract OT1-03-05: TROPION-Breast02: Phase 3, open-label, randomized study of first-line datopotamab deruxtecan versus chemotherapy in patients with locally recurrent inoperable or metastatic TNBC who are not candidates for anti-PD-(L)1 therapy","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Oncology; Phases of clinical research; Metastatic breast cancer; Neutropenia; Chemotherapy; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001650262,0.001544648,0.002053879,0.0003290893,0.0003985606,0.001561529,0.0009827563,0.001735872,0.01014876],"category_scores_gemma":[0.001008893,0.0006615244,0.001604197,0.000430641,0.001051001,0.001023217,0.0003727976,0.004147248,0.002078942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001279317,"about_ca_system_score_gemma":0.001568706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277719,"about_ca_topic_score_gemma":0.003286215,"domain_scores_codex":[0.9995939,0.0001883676,0.0000171009,0.00007548367,0.00003581532,0.00008923223],"domain_scores_gemma":[0.9992482,0.0001197055,0.0001409667,0.00005270158,0.00005437161,0.0003840678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9237917,0.03049957,0.001211319,0.0006804742,0.0009695047,0.00006722797,0.00008769125,0.0007982019,0.01013089,0.0002127497,0.003821749,0.02772881],"study_design_scores_gemma":[0.8111819,0.1829677,0.002198181,0.00003519437,0.00034483,0.00006513989,0.00003458346,0.0006544697,0.000812908,0.0001672298,0.001518138,0.00001976847],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792969,0.00337479,0.0008008974,0.001297581,0.0005755284,0.007175074,0.003482967,0.0002551783,0.003741231],"genre_scores_gemma":[0.9703019,0.002907939,0.001982188,0.002651884,0.0005079716,0.008057006,0.004326693,0.00008239203,0.00918196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01014876,"threshold_uncertainty_score":0.03395098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1828731618975911,"score_gpt":0.4921451045105572,"score_spread":0.3092719426129661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}