{"id":"W4322772114","doi":"10.1158/1538-7445.sabcs22-ot1-03-04","title":"Abstract OT1-03-04: Datopotamab deruxtecan (Dato-DXd), a TROP2 antibody-drug conjugate, vs investigators’ choice of chemotherapy in previously-treated, inoperable or metastatic HR+/HER2– breast cancer: TROPION-Breast01","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Medicine; Metastatic breast cancer; Vinorelbine; Eribulin; Internal medicine; Chemotherapy; Oncology; Breast cancer; Gemcitabine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001497059,0.0006987042,0.001559368,0.001300798,0.0002541547,0.0001138404,0.0009402231,0.0002073373,0.002909098],"category_scores_gemma":[0.0003093905,0.000563381,0.0002196862,0.005305398,0.000956941,0.0006117588,0.0001745206,0.001489108,0.0001548731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001351511,"about_ca_system_score_gemma":0.003177363,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03442941,"about_ca_topic_score_gemma":0.006034439,"domain_scores_codex":[0.9930933,0.0005679228,0.001124449,0.001326452,0.001864136,0.002023768],"domain_scores_gemma":[0.9960551,0.0007057321,0.000321119,0.00134891,0.0008618649,0.0007072189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0195697,0.002463315,0.3701061,0.008425505,0.001949048,0.002202152,0.01077066,0.0006349914,0.4210054,0.0002809978,0.01335756,0.1492346],"study_design_scores_gemma":[0.03674147,0.001787452,0.7128274,0.008836019,0.0003968103,0.0009498221,0.005712278,0.0006162822,0.1350003,0.0009607819,0.09405755,0.002113785],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825749,0.004060999,0.00001230542,0.009218251,0.0001846271,0.002750834,0.0006924819,0.0002505664,0.000255022],"genre_scores_gemma":[0.9852503,0.008520773,0.0004022588,0.0008207526,0.0004882349,0.001761175,0.0002523313,0.0002569314,0.00224724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3427213,"threshold_uncertainty_score":0.9996818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07280313990434058,"score_gpt":0.4282112842062609,"score_spread":0.3554081443019203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}