{"id":"W4322773921","doi":"10.3390/cancers15051554","title":"Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Beatrice Hunter Cancer Research Institute; New Brunswick Innovation Foundation; Leukemia and Lymphoma Society of Canada; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Chronic lymphocytic leukemia; Circular RNA; microRNA; Leukemia; Computational biology; RNA; Cancer research; Medicine; Biology; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196255,0.000177455,0.0001362635,0.00006100224,0.0001434443,0.00004091863,0.0001635053,0.0001380461,0.000006844657],"category_scores_gemma":[0.0003724607,0.0001718237,0.0001008628,0.000133414,0.0001344505,0.000004987002,0.00007814086,0.00004857395,0.000003250789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00204412,"about_ca_system_score_gemma":0.002397599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000392376,"about_ca_topic_score_gemma":0.00001163738,"domain_scores_codex":[0.9988983,0.00003908951,0.0001432211,0.0004596139,0.0001222929,0.0003374332],"domain_scores_gemma":[0.9993712,0.00009419035,0.00006886815,0.0003133778,0.0000424668,0.0001098886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008307948,0.000001961164,0.0002494108,0.0002558911,0.0001212015,0.00000927569,0.00004520862,0.009754718,0.9761558,0.00001086038,0.002888306,0.01042427],"study_design_scores_gemma":[0.002764529,0.0003050692,0.00318734,0.0003321953,0.0001676145,0.00001283197,0.0001974912,0.01510083,0.9521794,0.0004991206,0.02464886,0.0006046618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720091,0.0260047,0.0007446081,0.00003179489,0.0002594618,0.0007834114,0.00003676978,0.0000686514,0.00006149652],"genre_scores_gemma":[0.9979826,0.0008756459,0.00008113252,0.0001951012,0.0002664543,0.0003406269,0.0001270242,0.00005095737,0.00008041524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02597353,"threshold_uncertainty_score":0.7006767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211996769001279,"score_gpt":0.2679144797502612,"score_spread":0.2557945120602484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}