{"id":"W4322774011","doi":"10.1158/1538-7445.sabcs22-her2-06","title":"Abstract HER2-06: HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+) breast cancer patients - characterization of the molecular phenotype in combination with molecular subtyping","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Breast cancer; Medicine; Oncology; Internal medicine; Cancer; Neoadjuvant therapy; Biomarker; Hormone receptor; Stage (stratigraphy); Trastuzumab; Biopsy; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007000396,0.0003247159,0.0008152043,0.0009233947,0.0001253389,0.00002972043,0.0003910703,0.0001778657,0.0003303456],"category_scores_gemma":[0.0001181923,0.0002401199,0.0001890837,0.006280298,0.0004367084,0.0002378282,0.0001578039,0.000620625,0.00001388911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001034045,"about_ca_system_score_gemma":0.0005429728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003277661,"about_ca_topic_score_gemma":0.0005261279,"domain_scores_codex":[0.9959983,0.0003315709,0.0007276885,0.0006308487,0.001630966,0.000680691],"domain_scores_gemma":[0.9970314,0.000137855,0.0004430936,0.0006597362,0.001571649,0.000156247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003381665,0.0006344672,0.3481865,0.0005042413,0.001331026,0.00003347304,0.001654716,0.00249249,0.6293378,0.00009115818,0.00003443458,0.01231802],"study_design_scores_gemma":[0.002883349,0.0002726298,0.9242536,0.000949242,0.0002384739,0.000001367085,0.0002804913,0.0002933715,0.07043578,0.00003711118,0.0001135979,0.0002409828],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956532,0.000346524,0.0002741402,0.001603455,0.0000884654,0.001414354,0.0005058687,0.00004628173,0.00006776063],"genre_scores_gemma":[0.9979572,0.00042597,0.00005568133,0.0001537616,0.00004329003,0.0004114024,0.0005025981,0.0001018602,0.0003482951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5760671,"threshold_uncertainty_score":0.9791805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748631382203049,"score_gpt":0.3532675189050776,"score_spread":0.3257812050830471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}