{"id":"W4322774598","doi":"10.1158/1538-7445.sabcs22-p4-09-12","title":"Abstract P4-09-12: Baseline and End-of-Treatment Biomarkers in Patients With PIK3CA-Mutated, Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer From BYLieve Study Cohorts A and B","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Fulvestrant; Internal medicine; Oncology; Letrozole; Biomarker; Cancer; Breast cancer; Aromatase inhibitor; Cohort; Hazard ratio; Cancer research; Estrogen receptor; Biology; Confidence interval; Aromatase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001137068,0.0005292605,0.0008631845,0.0004436524,0.000378298,0.001096328,0.0007393301,0.0005220168,0.003347066],"category_scores_gemma":[0.001026535,0.0003051388,0.0007188579,0.0006538806,0.0003360858,0.0006572495,0.0007345526,0.001221405,0.001019399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000597597,"about_ca_system_score_gemma":0.0007274457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002059574,"about_ca_topic_score_gemma":0.00343552,"domain_scores_codex":[0.9994401,0.000175533,0.00003122613,0.0001654771,0.0001171601,0.00007052154],"domain_scores_gemma":[0.9988344,0.0001206025,0.0002897663,0.0001302281,0.0002718284,0.0003530839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08477785,0.002618201,0.8453019,0.0003716148,0.001319424,0.0001639181,0.000322947,0.000601051,0.01648031,0.0002987767,0.01413054,0.03361333],"study_design_scores_gemma":[0.009042167,0.01462535,0.9511371,0.00009646641,0.0007277027,0.000730923,0.0003023266,0.0006520988,0.003718247,0.0003026538,0.01861609,0.00004890853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753469,0.0008901602,0.0003949032,0.0002770048,0.0000465049,0.0004766882,0.01932013,0.00003370611,0.003214023],"genre_scores_gemma":[0.9077855,0.0004789575,0.001341698,0.0004585647,0.000105801,0.001168249,0.08480749,0.00005490622,0.003798873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003347066,"threshold_uncertainty_score":0.01119709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03477363102136186,"score_gpt":0.3609850733321113,"score_spread":0.3262114423107494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}