{"id":"W4322774598","doi":"10.1158/1538-7445.sabcs22-p4-09-12","title":"Abstract P4-09-12: Baseline and End-of-Treatment Biomarkers in Patients With PIK3CA-Mutated, Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer From BYLieve Study Cohorts A and B","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Fulvestrant; Internal medicine; Oncology; Letrozole; Biomarker; Cancer; Breast cancer; Aromatase inhibitor; Cohort; Hazard ratio; Cancer research; Estrogen receptor; Biology; Confidence interval; Aromatase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004710117,0.0004762122,0.0008913276,0.0005824246,0.0002339776,0.00003752371,0.000149155,0.0001253162,0.00062111],"category_scores_gemma":[0.00009994865,0.0003747846,0.00005549262,0.001066419,0.0007443809,0.0003632953,0.0001522076,0.0004961952,0.000007735051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001512204,"about_ca_system_score_gemma":0.000498581,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02297686,"about_ca_topic_score_gemma":0.003526399,"domain_scores_codex":[0.9962465,0.0003359515,0.0005619695,0.001060579,0.0009399859,0.0008549996],"domain_scores_gemma":[0.9975564,0.0006619407,0.0002192593,0.000397452,0.0007516335,0.0004133062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01663383,0.001013996,0.8049684,0.0001113167,0.001424139,0.00007402144,0.004772804,0.00003425169,0.04668402,0.00000267163,0.0001290392,0.1241516],"study_design_scores_gemma":[0.01873616,0.002546594,0.9640406,0.0006888966,0.0000779305,0.000002651523,0.002137186,0.00002055907,0.01125996,0.00003522441,0.00009806373,0.0003561808],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905475,0.001430706,0.000005140974,0.0007047047,0.00008500458,0.003314977,0.003778875,0.00007533724,0.00005769239],"genre_scores_gemma":[0.9961656,0.001661367,0.0003070235,0.00003368839,0.0001243943,0.001157536,0.0003461684,0.0001096105,0.00009461762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1590722,"threshold_uncertainty_score":0.9998704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03477363102136186,"score_gpt":0.3609850733321113,"score_spread":0.3262114423107494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}