{"id":"W4322775281","doi":"10.1158/1538-7445.sabcs22-p6-10-13","title":"Abstract P6-10-13: An update to a Phase I trial of CFI-402257, an oral TTK inhibitor, in patients with advanced solid tumors with HER2-negative breast cancer expansion cohorts","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; Ottawa Hospital","funders":"","keywords":"Medicine; Tolerability; Breast cancer; Cancer; Internal medicine; Oncology; Response Evaluation Criteria in Solid Tumors; Discontinuation; Fulvestrant; Progressive disease; Chemotherapy; Adverse effect; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001763724,0.001100868,0.001380418,0.0004053469,0.000416975,0.001185423,0.0008578095,0.001221764,0.005139677],"category_scores_gemma":[0.0007499444,0.0003867799,0.001002588,0.0004464005,0.0005392884,0.0007493857,0.0003207903,0.00410311,0.001202369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006749861,"about_ca_system_score_gemma":0.00131392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000899248,"about_ca_topic_score_gemma":0.002653277,"domain_scores_codex":[0.9996922,0.0001083422,0.00002022832,0.00005416303,0.00004953202,0.000075507],"domain_scores_gemma":[0.9994884,0.00008664843,0.00006427299,0.00003696639,0.00005633596,0.0002674226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2184681,0.03240417,0.009402248,0.002635882,0.002047618,0.001509746,0.0005867784,0.005016716,0.1564559,0.001818343,0.04864678,0.5210077],"study_design_scores_gemma":[0.4657246,0.4046305,0.02367371,0.0004108537,0.001522658,0.002555689,0.0001379984,0.004209453,0.02312449,0.001120391,0.0727756,0.0001141645],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396357,0.01440494,0.003723608,0.006116358,0.0008015257,0.009058462,0.007761218,0.0006505646,0.01784747],"genre_scores_gemma":[0.9224383,0.01447138,0.009577662,0.008676408,0.0006170481,0.008951728,0.01501977,0.0002343666,0.02001333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005139677,"threshold_uncertainty_score":0.01719391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02510565608824622,"score_gpt":0.3826312031732073,"score_spread":0.3575255470849611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}