{"id":"W4322775372","doi":"10.1158/1538-7445.sabcs22-p3-07-04","title":"Abstract P3-07-04: A multicenter, single-arm, open-label Phase I study of AN1004 (Pelareorep) oncolytic virus plus paclitaxel in Chinese patients with Hormone receptor-positive and HER2-negative advanced/metastatic breast cancer (REO 026-1)","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Metastatic breast cancer; Breast cancer; Tolerability; Internal medicine; Oncology; Oncolytic virus; Regimen; Cancer; Population; Response Evaluation Criteria in Solid Tumors; Paclitaxel; Phases of clinical research; Chemotherapy; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001791121,0.001722933,0.001725101,0.0005153841,0.0005656568,0.0007277324,0.001197813,0.001212334,0.003620633],"category_scores_gemma":[0.000687009,0.0005807077,0.001421339,0.0005036523,0.0009471849,0.0007911357,0.000361774,0.003296138,0.0008143589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001154712,"about_ca_system_score_gemma":0.002946289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002499146,"about_ca_topic_score_gemma":0.005207495,"domain_scores_codex":[0.9995723,0.0001682841,0.00002093541,0.00009177568,0.00004821884,0.0000983699],"domain_scores_gemma":[0.9992784,0.00007517239,0.0001243861,0.00007206391,0.00006625815,0.0003838681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5980232,0.1659014,0.007494931,0.0007179769,0.001303951,0.0003314817,0.0005446644,0.002404988,0.1438859,0.0003375995,0.00422488,0.07482892],"study_design_scores_gemma":[0.4311765,0.5481337,0.009711857,0.00001757369,0.000405641,0.0001960897,0.00006874441,0.0009931989,0.007198954,0.0001039402,0.001960215,0.00003352265],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938689,0.0005033215,0.0004702289,0.000220459,0.00006054448,0.00285262,0.0009564777,0.00009431825,0.0009731404],"genre_scores_gemma":[0.9863927,0.0007384206,0.002369764,0.0005757792,0.0001175132,0.003800166,0.002575324,0.00004390183,0.003386351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003620633,"threshold_uncertainty_score":0.0121122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05422563913454027,"score_gpt":0.4234907528237706,"score_spread":0.3692651136892303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}