{"id":"W4322775512","doi":"10.1158/1538-7445.sabcs22-p5-02-14","title":"Abstract P5-02-14: Identification of mechanisms of acquired resistance to ribociclib plus endocrine therapy using baseline and end-of-treatment circulating tumor DNA samples in the MONALEESA-2, -3, and -7 trials","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003695279,0.0001429296,0.0006039895,0.0003688858,0.000080492,0.00001517764,0.0001344924,0.00003413486,0.00005107765],"category_scores_gemma":[0.0007223421,0.0001023909,0.00006235719,0.0008177836,0.0002325902,0.00008477027,0.00005082849,0.000084,4.604183e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003115489,"about_ca_system_score_gemma":0.0003933079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001295715,"about_ca_topic_score_gemma":0.0002808533,"domain_scores_codex":[0.9976193,0.0003602748,0.0007553549,0.0003357272,0.0006127568,0.0003165556],"domain_scores_gemma":[0.9974238,0.001504374,0.0002932712,0.0003706912,0.0003352286,0.00007260456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001815191,0.0000570284,0.001457493,0.0003858512,0.00009003213,0.00001504459,0.002347489,0.0004072764,0.9625429,0.0004329468,0.000007787083,0.03044096],"study_design_scores_gemma":[0.004890579,0.000336734,0.08008513,0.0009434103,0.00004287565,0.00001364815,0.003341812,0.0004508047,0.9045116,0.004872831,0.0003790162,0.0001315487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919433,0.00473073,0.0006242416,0.001020954,0.00003988145,0.001395038,0.0002190324,0.00001342358,0.00001338149],"genre_scores_gemma":[0.9971616,0.001405808,0.0009750068,0.00002632829,0.00007530295,0.0002426143,0.00002155695,0.00002749774,0.00006428477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07862764,"threshold_uncertainty_score":0.417538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2759882814859952,"score_gpt":0.4773927299427702,"score_spread":0.201404448456775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}