{"id":"W4322775512","doi":"10.1158/1538-7445.sabcs22-p5-02-14","title":"Abstract P5-02-14: Identification of mechanisms of acquired resistance to ribociclib plus endocrine therapy using baseline and end-of-treatment circulating tumor DNA samples in the MONALEESA-2, -3, and -7 trials","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Internal medicine; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003334312,0.0003940941,0.000867187,0.0002814506,0.0001671506,0.0009862455,0.0004569442,0.0004847509,0.003404348],"category_scores_gemma":[0.001966573,0.000164817,0.0008557608,0.0003731498,0.0002974714,0.0005356866,0.0003936354,0.001146057,0.0004112957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006184402,"about_ca_system_score_gemma":0.0008533416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000442605,"about_ca_topic_score_gemma":0.001931141,"domain_scores_codex":[0.998596,0.0008483767,0.00009864368,0.0001870317,0.0001759096,0.0000939737],"domain_scores_gemma":[0.9985763,0.00038162,0.000472219,0.00011712,0.0001761819,0.0002765241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.597933,0.004472693,0.1438425,0.002086187,0.007435436,0.0001598472,0.0002906422,0.001682321,0.04319276,0.0005153135,0.006056918,0.1923325],"study_design_scores_gemma":[0.1662565,0.1912361,0.5932863,0.0004023821,0.006992417,0.0008959423,0.0002806837,0.004586868,0.01743421,0.0006763076,0.01786584,0.00008632625],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850306,0.005654294,0.000481477,0.0005043223,0.00003775163,0.0008902765,0.00349367,0.0000640021,0.003843653],"genre_scores_gemma":[0.992965,0.0006032926,0.0006472529,0.0004120378,0.00006136674,0.0005336829,0.003493482,0.00001095445,0.001272989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003404348,"threshold_uncertainty_score":0.01763374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2759882814859952,"score_gpt":0.4773927299427702,"score_spread":0.201404448456775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}