{"id":"W4323035491","doi":"10.1139/cjpp-2022-0428","title":"Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1<i>H</i>-pyrazol-4-yl)-1<i>H</i>-tetrazole: role of NO/cGMP pathway and calcium channels","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pharmacology; Chemistry; Licking; Nociception; Tetrazole; Phenylephrine; Carrageenan; Anesthesia; Medicine; Stereochemistry; Receptor; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008607129,0.0002417096,0.0002230775,0.0001351133,0.0001394143,0.0001239714,0.0002833091,0.000292369,0.0008886352],"category_scores_gemma":[0.00006715152,0.00008046648,0.0001807118,0.00009332161,0.000135634,0.0001774019,0.00009225577,0.0004884695,0.0001594143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866942,"about_ca_system_score_gemma":0.0001921742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004201034,"about_ca_topic_score_gemma":0.001366316,"domain_scores_codex":[0.9999528,0.000006400938,0.000004574217,0.000009141121,0.00001209272,0.00001509731],"domain_scores_gemma":[0.9999567,0.000004545898,0.00001605232,0.000003599883,0.000007420073,0.00001165509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343076,0.00008631706,0.0001639732,0.0001157136,0.000005704417,0.0001233193,0.00001046826,0.0001006622,0.9952987,0.0001022277,0.00007193616,0.003786719],"study_design_scores_gemma":[0.0001381102,0.005066274,0.008520004,0.00002774957,0.00005708251,0.001129742,0.00003625431,0.001395004,0.9776408,0.00009283511,0.005878794,0.00001736801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811879,0.01090351,0.004552278,0.0004042109,0.00008263643,0.00006188834,0.0003170558,0.0001302318,0.002360385],"genre_scores_gemma":[0.991643,0.003645882,0.002914482,0.000129671,0.00002704766,0.00003490038,0.0002773188,0.000005887974,0.001321917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008886352,"threshold_uncertainty_score":0.002972841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008232394786165465,"score_gpt":0.2302114908781349,"score_spread":0.2219790960919694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}