{"id":"W4323035504","doi":"10.1007/s00223-023-01065-4","title":"Mitigating the Denosumab-Induced Rebound Phenomenon with Alternating Short- and Long-Acting Anti-resorptive Therapy in a Young Boy with Severe OI Type VI","year":2023,"lang":"en","type":"article","venue":"Calcified Tissue International","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Children's Hospital; McGill University; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Denosumab; Osteogenesis imperfecta; Medicine; Osteomalacia; Internal medicine; Zoledronic acid; Endocrinology; Calcium metabolism; Parathyroid hormone; Osteoporosis; Creatinine; Calcium; Urology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002898486,0.0001836617,0.0001440668,0.0001150429,0.0001522081,0.0001234582,0.0002892727,0.00007666937,0.00003506121],"category_scores_gemma":[0.0001635467,0.0001378626,0.00002069533,0.0002985874,0.00009473586,0.00001934213,0.0001552375,0.0002364021,0.000008328821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005299399,"about_ca_system_score_gemma":0.00008385848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000243342,"about_ca_topic_score_gemma":0.001041648,"domain_scores_codex":[0.9986246,0.00008557591,0.0001828081,0.0004544915,0.0003378219,0.0003146657],"domain_scores_gemma":[0.9993458,0.0000795364,0.00007618085,0.0002082234,0.0002366944,0.00005353578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009404869,0.00008311425,0.2828954,0.00002672647,0.0004535394,0.0001771359,0.002784574,0.0005819642,0.6608707,0.0002731624,0.00009769231,0.05081545],"study_design_scores_gemma":[0.007419974,0.003239929,0.6269578,0.0005600579,0.00003929152,0.0006654077,0.01334814,0.006241139,0.3349618,0.0004602713,0.004466775,0.00163936],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963285,0.0002946922,0.000300253,0.0005247865,0.0001117255,0.0003921563,0.0000102961,0.00002401972,0.002013569],"genre_scores_gemma":[0.9987302,0.0001099949,0.000116276,0.00005804969,0.0001962259,0.00006151547,0.0001047443,0.00004211766,0.0005808561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3440624,"threshold_uncertainty_score":0.5621873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03827990089735746,"score_gpt":0.3371432191719114,"score_spread":0.298863318274554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}