{"id":"W4323035553","doi":"10.1139/cjpp-2022-0408","title":"Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Curcumin; Pharmacology; Bioavailability; Pharmacokinetics; In vivo; Human serum albumin; Chemistry; Toxicity; ADME; Therapeutic index; Drug; Medicine; Biochemistry; Biology; Biotechnology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004469509,0.0001586011,0.0003396381,0.0001679144,0.0002013632,0.000004921113,0.0002903084,0.0002598582,0.000520349],"category_scores_gemma":[0.00002832629,0.0001409496,0.0001548204,0.0001694342,0.0007447787,0.000006426526,0.00005058129,0.0002137504,0.000005471838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001867046,"about_ca_system_score_gemma":0.0003927181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005264048,"about_ca_topic_score_gemma":0.00007043742,"domain_scores_codex":[0.9986606,0.0001919447,0.0004392003,0.0002452064,0.00005839126,0.0004046395],"domain_scores_gemma":[0.9989281,0.0001047409,0.0002606327,0.0001034522,0.0001893161,0.0004137721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002409943,0.00004181981,0.0002826531,0.00004696089,0.0002951414,0.00001451238,0.00005048473,0.00005071922,0.985889,0.000304764,0.01088559,0.00189735],"study_design_scores_gemma":[0.002432917,0.001024122,0.007794604,0.000006615835,0.0002822457,0.00010083,0.00005385809,0.0001320636,0.8470423,0.0029053,0.1380306,0.0001946533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943009,0.001094937,0.0009280498,0.002222211,0.0007458905,0.0003750447,0.0002702864,0.000006341661,0.00005632946],"genre_scores_gemma":[0.9974667,0.0003055663,0.0001331936,0.001080111,0.0006250367,0.00003215038,0.0001127865,0.00001713633,0.0002273479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1388468,"threshold_uncertainty_score":0.5747759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872584550628948,"score_gpt":0.3202931077521939,"score_spread":0.3015672622459044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}