{"id":"W4323036146","doi":"10.1007/s10637-023-01342-x","title":"Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors","year":2023,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute","keywords":"Peripheral blood mononuclear cell; Medicine; CD8; Tolerability; Immune system; Antigen; Pharmacodynamics; Immunotherapy; Immunology; Human leukocyte antigen; Pharmacology; Adverse effect; Internal medicine; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009643101,0.0006508845,0.000896086,0.0001772601,0.0002359589,0.0004308868,0.0003294817,0.0006314643,0.002361214],"category_scores_gemma":[0.0005027372,0.0002872816,0.0004828986,0.0001226754,0.0004280401,0.000342361,0.0001867062,0.00153405,0.0004343754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003681819,"about_ca_system_score_gemma":0.0006109186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001795297,"about_ca_topic_score_gemma":0.0003510067,"domain_scores_codex":[0.999714,0.0001313245,0.000012016,0.00005803539,0.00003319,0.00005152076],"domain_scores_gemma":[0.999624,0.00009076437,0.00009671247,0.00004642179,0.00003058156,0.0001114016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2466743,0.1413148,0.02111674,0.0005019706,0.0004583591,0.0005022637,0.000628044,0.005512056,0.4517749,0.0006157174,0.00336596,0.1275348],"study_design_scores_gemma":[0.03870027,0.9266506,0.008471669,0.00001030634,0.00009187239,0.0002456849,0.00004823702,0.001386289,0.02205032,0.0001530194,0.002179695,0.00001201782],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973618,0.0002386475,0.0005995529,0.00008056202,0.00003697781,0.001036141,0.0002179519,0.00002494786,0.0004033693],"genre_scores_gemma":[0.9938883,0.0002233586,0.001853558,0.0003082799,0.00007400495,0.001616821,0.000525731,0.00001352067,0.001496325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361214,"threshold_uncertainty_score":0.007899046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04542277026582583,"score_gpt":0.3424850493680232,"score_spread":0.2970622791021974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}