{"id":"W4323036146","doi":"10.1007/s10637-023-01342-x","title":"Phase 1 study to determine the safety and dosing of autologous PBMCs modified to present HPV16 antigens (SQZ-PBMC-HPV) in HLA-A*02+ patients with HPV16+ solid tumors","year":2023,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute","keywords":"Peripheral blood mononuclear cell; Medicine; CD8; Tolerability; Immune system; Antigen; Pharmacodynamics; Immunotherapy; Immunology; Human leukocyte antigen; Pharmacology; Adverse effect; Internal medicine; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000655505,0.0002451754,0.0004807908,0.0004609641,0.0001348571,0.00003852747,0.0002306742,0.00005219509,0.0001464818],"category_scores_gemma":[0.0003382236,0.000175936,0.00005055867,0.001293197,0.0002339347,0.00009381686,0.0002200552,0.0002626347,0.00002540426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375192,"about_ca_system_score_gemma":0.000531893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006892707,"about_ca_topic_score_gemma":0.0001749534,"domain_scores_codex":[0.9971601,0.0001732154,0.0006017559,0.0004920959,0.001116181,0.0004566629],"domain_scores_gemma":[0.9982651,0.0004113993,0.0001197146,0.0004521525,0.0002397614,0.0005118693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01557276,0.006127898,0.6106052,0.0003527,0.0007781004,0.0004954622,0.09929199,0.02444713,0.09129136,0.0004619815,0.009926584,0.1406488],"study_design_scores_gemma":[0.0169782,0.004409682,0.9494712,0.0003017879,0.00008551213,0.00002546981,0.001880954,0.008083214,0.01623179,0.0005546024,0.001562916,0.0004146242],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912015,0.00002307442,0.00005986715,0.005430167,0.0000664874,0.002699048,0.00005247003,0.00005942896,0.0004079839],"genre_scores_gemma":[0.9963501,0.000005654946,0.0005883424,0.0006943876,0.0001322584,0.00006201673,0.00009360824,0.00004474048,0.002028898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3388661,"threshold_uncertainty_score":0.7174463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04542277026582583,"score_gpt":0.3424850493680232,"score_spread":0.2970622791021974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}