{"id":"W4323036645","doi":"10.1080/21645515.2023.2177066","title":"Phase 3 trial to evaluate the safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, followed by 23-valent pneumococcal polysaccharide vaccine 6 months later, in at-risk adults 18–49 years of age (PNEU-DAY): A subgroup analysis by baseline risk factors","year":2023,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Immunogenicity; Pneumococcal conjugate vaccine; Tolerability; Medicine; Pneumococcal vaccine; Pneumococcal polysaccharide vaccine; Immunology; Pneumococcal disease; Streptococcus pneumoniae; Virology; Adverse effect; Internal medicine; Microbiology; Antigen; Biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002402458,0.001284848,0.002134781,0.0002825419,0.0003331072,0.0006787271,0.0005460024,0.001326584,0.003113704],"category_scores_gemma":[0.002654339,0.000443411,0.003625187,0.0003291091,0.0004488005,0.0007090404,0.0002969367,0.00223166,0.0005202856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007028081,"about_ca_system_score_gemma":0.001533269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132142,"about_ca_topic_score_gemma":0.002285387,"domain_scores_codex":[0.9991544,0.0005110235,0.00004463456,0.0001254705,0.00004719535,0.000117276],"domain_scores_gemma":[0.9985838,0.000443007,0.0003861416,0.000137843,0.0001209576,0.0003282396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.975822,0.005140538,0.003064234,0.0003308839,0.002147967,0.00005656183,0.00007445925,0.0003419955,0.003276034,0.00006770895,0.0005647047,0.009112899],"study_design_scores_gemma":[0.7240165,0.2616771,0.009808856,0.00005270471,0.001735452,0.00009326951,0.0000455286,0.0006558042,0.0009668818,0.0002317356,0.0006937507,0.00002239374],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930642,0.001709531,0.0004024403,0.0002190421,0.0001275561,0.002477313,0.001102966,0.00004185837,0.0008552436],"genre_scores_gemma":[0.9905743,0.0009439634,0.001120195,0.000633787,0.0001769716,0.003506326,0.001656598,0.00002049439,0.001367291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003113704,"threshold_uncertainty_score":0.01270556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02227498377761634,"score_gpt":0.3186826281464151,"score_spread":0.2964076443687988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}