{"id":"W4323037649","doi":"10.1093/neuonc/noad053","title":"Atypical neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Friedberg Charitable Foundation; Deutsche Krebshilfe","keywords":"Malignant peripheral nerve sheath tumor; Epigenetics; CDKN2A; Pathology; Neurofibromatosis; Malignant transformation; Neurofibroma; Biology; DNA methylation; Cancer research; Medicine; Internal medicine; Cancer; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001988339,0.0004330576,0.0008702709,0.0002508848,0.0002625788,0.00007473877,0.000263025,0.0001639695,0.0001785736],"category_scores_gemma":[0.0004386879,0.000336829,0.0002052027,0.0007078708,0.0002667177,0.0001157176,0.000252846,0.0005907884,0.000177473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001360525,"about_ca_system_score_gemma":0.0004107624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004980584,"about_ca_topic_score_gemma":0.00007656596,"domain_scores_codex":[0.9967905,0.0003913968,0.0005049511,0.0009370612,0.0005227755,0.0008532921],"domain_scores_gemma":[0.9980065,0.0004786999,0.0001312304,0.0006502942,0.0001344908,0.0005988237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009927474,0.0009555399,0.132815,0.0005075967,0.0001356489,0.04106841,0.001170072,0.000106175,0.6990446,0.001719125,0.1062472,0.00630315],"study_design_scores_gemma":[0.003393885,0.01894386,0.8468235,0.0001427503,0.0002701808,0.01057442,0.0003366791,0.0001763476,0.03555514,0.0002180312,0.08291879,0.0006464091],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868251,0.00008244069,0.00003607262,0.007639418,0.0006670916,0.001152002,0.00005159784,0.0004801052,0.003066156],"genre_scores_gemma":[0.9938207,0.00001141632,0.0008501734,0.003077127,0.0005461658,0.0002150895,0.00005856803,0.0001083357,0.001312473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7140086,"threshold_uncertainty_score":0.9999084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322527932694977,"score_gpt":0.2864650449770008,"score_spread":0.263239765650051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}