{"id":"W4323037649","doi":"10.1093/neuonc/noad053","title":"Atypical neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Friedberg Charitable Foundation; Deutsche Krebshilfe","keywords":"Malignant peripheral nerve sheath tumor; Epigenetics; CDKN2A; Pathology; Neurofibromatosis; Malignant transformation; Neurofibroma; Biology; DNA methylation; Cancer research; Medicine; Internal medicine; Cancer; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814312,0.0001368117,0.0001759907,0.0007802693,0.0001634388,0.00028286,0.0001244214,0.0001746309,0.001121679],"category_scores_gemma":[0.0006027406,0.00009279689,0.000107773,0.0004427677,0.0002973492,0.0002270962,0.0002732852,0.0001220987,0.0001881647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001578111,"about_ca_system_score_gemma":0.0001144046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005721383,"about_ca_topic_score_gemma":0.001400847,"domain_scores_codex":[0.9998413,0.00001702771,0.00002142512,0.00005234226,0.00004009563,0.00002772574],"domain_scores_gemma":[0.9995857,0.00009104828,0.000165492,0.0000406758,0.00006049451,0.00005654351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007390236,0.00003765573,0.6763426,0.0001243125,0.00009796303,0.002666281,0.0006024974,0.0003672264,0.3017753,0.0002858956,0.00009723971,0.01686396],"study_design_scores_gemma":[0.0000061606,0.0001043038,0.967188,0.000008238566,0.00005872627,0.01066772,0.0003367634,0.0009812844,0.0192823,0.0003816931,0.000974722,0.00001007859],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986745,0.0001767129,0.0006934401,0.00000889373,0.000001376421,0.000006579776,0.00006877443,0.0000115657,0.0003582596],"genre_scores_gemma":[0.9990262,0.00006808401,0.0006643363,0.000005619813,0.000003009234,0.000006348515,0.00009874152,0.000002932517,0.0001248373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121679,"threshold_uncertainty_score":0.003752351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322527932694977,"score_gpt":0.2864650449770008,"score_spread":0.263239765650051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}