{"id":"W4323038294","doi":"10.1101/2023.03.01.530657","title":"Small Molecule Screen Identifies Non-Catalytic USP3 Chemical Handle","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Canada Research Chairs; Ontario Institute for Cancer Research; York University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Genentech; Québec Consortium for Drug Discovery; Ontario Genomics Institute; Peterborough K. M. Hunter Charitable Foundation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Mitacs; Ontario Genomics; Genome Canada; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Ubiquitin; Chemistry; Bifunctional; Deubiquitinating enzyme; Molecule; Zinc finger; Cleavage (geology); Stereochemistry; Small molecule; Hydrogen–deuterium exchange; Catalysis; Combinatorial chemistry; Cell biology; Biochemistry; Nanotechnology; Hydrogen; Biology; Materials science; Transcription factor; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001296631,0.0005881433,0.0005451293,0.0009031701,0.0002533875,0.000362301,0.0003880177,0.0003946224,0.01398756],"category_scores_gemma":[0.0001205143,0.0001712726,0.0003702699,0.0005536302,0.0001289676,0.0001308667,0.0003140428,0.0003046412,0.00338456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995857,"about_ca_system_score_gemma":0.00032938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008278685,"about_ca_topic_score_gemma":0.001407529,"domain_scores_codex":[0.9998657,0.0000147185,0.00000845171,0.00002937049,0.00005025099,0.00003142899],"domain_scores_gemma":[0.9999202,0.00001676971,0.00001017603,0.000009828731,0.00001598033,0.0000269969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004918817,0.0003226134,0.0005490632,0.0002080951,0.00004213742,0.0002632963,0.00001631656,0.0008276656,0.9792668,0.0005056059,0.001458798,0.01604756],"study_design_scores_gemma":[0.0001368447,0.001812867,0.001438304,0.00001820631,0.00007829918,0.0003285719,0.00002033404,0.0009812627,0.9832409,0.0001231696,0.01180606,0.00001517876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9138153,0.005390184,0.01697112,0.0006033386,0.0001599639,0.001095712,0.02068155,0.002057953,0.03922493],"genre_scores_gemma":[0.9347656,0.004271381,0.01230479,0.0003321533,0.00002962961,0.0003574035,0.01473771,0.0001870168,0.03301434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01398756,"threshold_uncertainty_score":0.0467931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02515386200764834,"score_gpt":0.2287940649814843,"score_spread":0.2036402029738359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}