{"id":"W4323046146","doi":"10.3389/fonc.2023.1144056","title":"Project Optimus, an FDA initiative: Considerations for cancer drug development internationally, from an academic perspective","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Drug development; Medicine; Clinical trial; Excellence; Cancer drugs; Drug; Pharmacology; Political science; Internal medicine; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.1984479,0.001740656,0.002008377,0.001993061,0.007189682,0.03132473,0.007317855,0.03328308,0.01918246],"category_scores_gemma":[0.1222217,0.001136076,0.003243155,0.00277224,0.01256574,0.0229639,0.01297586,0.02687331,0.01048442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008245869,"about_ca_system_score_gemma":0.09945121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004904503,"about_ca_topic_score_gemma":0.007144517,"domain_scores_codex":[0.8865734,0.06068138,0.00595176,0.006227486,0.03078525,0.009780644],"domain_scores_gemma":[0.8061204,0.04248513,0.009746134,0.009270431,0.06491093,0.06746699],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005566476,0.0004991263,0.0008732856,0.0007648105,0.00006000893,0.0004753478,0.00106685,0.0005453529,0.001422754,0.1378718,0.73146,0.1244041],"study_design_scores_gemma":[0.0002753376,0.001007353,0.000618375,0.0008525181,0.00003918402,0.0005511887,0.0006004318,0.0003905596,0.000490936,0.02710561,0.9679881,0.00008044587],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001167575,0.01367339,0.00710074,0.9359455,0.01362896,0.0003763674,0.0001798214,0.0004030197,0.02752469],"genre_scores_gemma":[0.03780447,0.02134294,0.06760388,0.7963223,0.01724438,0.002495771,0.0008744033,0.0007794665,0.05553239],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.8015521,"threshold_uncertainty_score":0.9884565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04628795613636401,"score_gpt":0.385014430783936,"score_spread":0.338726474647572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}