{"id":"W4323048249","doi":"10.1038/s41467-023-36692-w","title":"The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Diamond Light Source; Canadian Light Source","keywords":"Netrin; Heparan sulfate; Axon guidance; Cell biology; Glycosaminoglycan; Heparin; Protein filament; Chemistry; Biophysics; Biology; Biochemistry; Axon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003792534,0.0001020084,0.000116431,0.0000614716,0.001147112,0.00006026785,0.00103935,0.0001476091,0.000001979319],"category_scores_gemma":[0.001125659,0.00005868456,0.00007746959,0.0004777808,0.0002451438,0.0001321511,0.0003143172,0.0007640189,0.000002320312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003558309,"about_ca_system_score_gemma":0.00002926422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000581343,"about_ca_topic_score_gemma":0.0001224069,"domain_scores_codex":[0.9989903,0.0001984711,0.0002464188,0.0001509013,0.0002307074,0.0001832166],"domain_scores_gemma":[0.9951423,0.003692892,0.0001896588,0.0008710649,0.00007604494,0.00002806848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005647789,0.00005019165,0.0002192872,0.00007998751,0.00005441349,0.000001032074,0.002557414,0.0001480648,0.5282394,0.424194,0.004184884,0.03970648],"study_design_scores_gemma":[0.005808215,0.0003600739,0.03070185,0.0002377096,0.0002110513,0.00005622165,0.003294281,0.3143613,0.5119749,0.03096481,0.1012534,0.0007761615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660826,0.003254445,0.00007828524,0.02849074,0.0003573297,0.001151685,0.00011105,0.00008368112,0.0003902444],"genre_scores_gemma":[0.9968993,0.001683255,0.0001793613,0.00097668,0.00002033502,0.0001252686,0.00002544346,0.00001102973,0.00007931704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3932292,"threshold_uncertainty_score":0.8822775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0347884397273592,"score_gpt":0.3290482120072231,"score_spread":0.2942597722798639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}