{"id":"W4323048429","doi":"10.1021/acsmedchemlett.3c00033","title":"Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"British Heart Foundation; University of Alberta","keywords":"Sarcomere; Troponin I; Activator (genetics); Biophysics; Chemistry; Cardiac muscle; Calcium; Troponin; Troponin C; Binding site; Myocyte; Biochemistry; Cell biology; Receptor; Anatomy; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181131,0.0001985585,0.0005339299,0.00006246941,0.00007031466,0.000007308699,0.0001248542,0.0001010343,0.0000511284],"category_scores_gemma":[0.0001135532,0.0001812604,0.0001263201,0.0003311452,0.0001338854,0.0001064956,0.00009383063,0.0001976833,0.00002530478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008693457,"about_ca_system_score_gemma":0.00005587505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000220508,"about_ca_topic_score_gemma":5.574315e-7,"domain_scores_codex":[0.9984794,0.00002987382,0.0002469417,0.0004154562,0.0005338886,0.0002944499],"domain_scores_gemma":[0.9988648,0.00007679766,0.00007240995,0.0005091837,0.00008646207,0.0003903071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002485099,0.00004942223,0.003793599,0.0001657973,0.0001159369,0.000092489,0.001859278,0.000004712837,0.9791201,4.229561e-7,0.01272692,0.001822765],"study_design_scores_gemma":[0.000924491,0.0001575048,0.06194277,0.0002205575,0.0002379747,0.000009707777,0.004219999,0.0000224384,0.9223051,0.000003622549,0.00975391,0.000201949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947128,0.00009622543,0.00001357752,0.00417548,0.0003953209,0.0002057698,0.00008669661,0.000138049,0.0001760573],"genre_scores_gemma":[0.9959438,0.00003086967,0.000119072,0.001989775,0.001578619,0.0000238469,0.0002219822,0.00003024817,0.00006177816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05814917,"threshold_uncertainty_score":0.7391583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475134017187881,"score_gpt":0.2701255006108561,"score_spread":0.2553741604389773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}