{"id":"W4323048429","doi":"10.1021/acsmedchemlett.3c00033","title":"Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"British Heart Foundation; University of Alberta","keywords":"Sarcomere; Troponin I; Activator (genetics); Biophysics; Chemistry; Cardiac muscle; Calcium; Troponin; Troponin C; Binding site; Myocyte; Biochemistry; Cell biology; Receptor; Anatomy; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007177849,0.0001956704,0.0001257258,0.0001319965,0.0001072434,0.0001476148,0.000199228,0.0001582126,0.001715552],"category_scores_gemma":[0.0001000349,0.0001011291,0.0001307255,0.0001265439,0.0001304181,0.000135965,0.0001163181,0.0003373258,0.0002729878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000153776,"about_ca_system_score_gemma":0.0001854382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004061855,"about_ca_topic_score_gemma":0.0006231525,"domain_scores_codex":[0.9999419,0.000006394633,0.000004141383,0.00001558046,0.00001299036,0.00001892894],"domain_scores_gemma":[0.999963,0.000005811153,0.000009604427,0.000004825873,0.000004905588,0.00001173301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008321216,0.00003666641,0.0000751947,0.00003936501,0.000006283984,0.00003843699,0.00001020561,0.00008507149,0.9965026,0.0003014579,0.00004689674,0.002774534],"study_design_scores_gemma":[0.00003558866,0.0007477897,0.0006874917,0.00000561928,0.00001667696,0.00009568217,0.000009065043,0.0003755241,0.9930235,0.00003535345,0.00496359,0.00000404158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873939,0.001052385,0.004018656,0.0000923579,0.00004346117,0.00008167051,0.0002247168,0.00008153277,0.007011435],"genre_scores_gemma":[0.9924852,0.0008967339,0.003027304,0.00007818147,0.00001150588,0.00004552516,0.0002027111,0.00001844853,0.003234394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715552,"threshold_uncertainty_score":0.005739033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475134017187881,"score_gpt":0.2701255006108561,"score_spread":0.2553741604389773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}