{"id":"W4323050795","doi":"10.1158/1538-7445.sabcs22-p3-07-14","title":"Abstract P3-07-14: A phase II study of CFI-400945 in patients with advanced/metastatic cancer: Canadian Cancer Trials Group (CCTG) IND.237","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Sunnybrook Health Science Centre; Health Sciences Centre; University Health Network; Ottawa Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cancer; Internal medicine; Oncology; Breast cancer; Taxane; PTEN; Neutropenia; Cohort; Metastatic breast cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001708604,0.001525007,0.001900248,0.000457409,0.0008369357,0.0008752529,0.001217664,0.001429658,0.01100756],"category_scores_gemma":[0.0007855578,0.0004920517,0.001051886,0.0007959112,0.0009329116,0.0003998301,0.0003653108,0.003509807,0.001809288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004187339,"about_ca_system_score_gemma":0.01153595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0532376,"about_ca_topic_score_gemma":0.135777,"domain_scores_codex":[0.9994919,0.0001559923,0.00001630331,0.00007017322,0.0001086512,0.000156881],"domain_scores_gemma":[0.9994352,0.00005617722,0.00006231965,0.00003716787,0.00008398808,0.0003250958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6408305,0.04988442,0.008050634,0.001857371,0.001676888,0.0006787994,0.0005221143,0.003936284,0.04850128,0.001011572,0.06220334,0.1808468],"study_design_scores_gemma":[0.7590741,0.1986352,0.01973915,0.0001057902,0.0005135772,0.0004187965,0.00009614004,0.00140624,0.003223146,0.0003264617,0.01640103,0.00006043997],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359576,0.005781131,0.001249632,0.003007532,0.000337886,0.02065591,0.01574833,0.0004221442,0.01683993],"genre_scores_gemma":[0.9313535,0.005193238,0.005352134,0.004055544,0.0002990986,0.01461519,0.01847509,0.0001489821,0.0205073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0532376,"threshold_uncertainty_score":0.1058555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1545150381215442,"score_gpt":0.4915499727596945,"score_spread":0.3370349346381503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}