{"id":"W4323066767","doi":"10.1111/1759-7714.14825","title":"Clinical and genomic features of non‐small cell lung cancer occurring in families","year":2023,"lang":"en","type":"article","venue":"Thoracic Cancer","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Kobayashi Foundation for Cancer Research","keywords":"Germline; Nonsynonymous substitution; Genetics; Germline mutation; Exome; Carcinogenesis; Exome sequencing; Lung cancer; Somatic cell; Gene; Medicine; Biology; Mutation; Genome; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447139,0.0001051577,0.0001705018,0.0000595276,0.000029143,0.000009733688,0.0001093899,0.00009663861,0.00001326704],"category_scores_gemma":[0.0000123852,0.00009847766,0.00006665327,0.0001027028,0.00007549753,0.000001721419,0.0001424785,0.00007865805,0.00000152148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001127477,"about_ca_system_score_gemma":0.0001459294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000573506,"about_ca_topic_score_gemma":0.001309174,"domain_scores_codex":[0.9992687,0.00002838075,0.0002013818,0.0002685993,0.00004855417,0.000184416],"domain_scores_gemma":[0.9996649,0.00001307756,0.00006527183,0.0001658282,0.00003136703,0.00005955263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001541058,0.00004581622,0.7099391,0.0003353574,0.00006141639,0.00001168415,0.000286853,0.001010429,0.2510084,0.000005084962,0.002781208,0.03436049],"study_design_scores_gemma":[0.0005322817,0.00004655775,0.9593305,0.00009674477,0.00005934331,0.000001874149,0.0003286091,0.0004143677,0.03302101,0.00002189988,0.005898488,0.0002483526],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845007,0.01466137,0.000009482231,0.00004364849,0.0002153234,0.0001429072,0.0001221929,0.000007184904,0.000297159],"genre_scores_gemma":[0.9845937,0.01439792,0.00007506858,0.0001387735,0.0001878507,0.00004489305,0.00002387505,0.0000176743,0.0005202843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2493913,"threshold_uncertainty_score":0.4015802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579160679204811,"score_gpt":0.350077222367807,"score_spread":0.3342856155757589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}