{"id":"W4323075798","doi":"10.1016/j.clim.2023.109274","title":"Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis","year":2023,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; McMaster University","funders":"National Center for Advancing Translational Sciences; National Eye Institute; National Center for Research Resources; EMD Serono; Genentech; National Institutes of Health; Sierra Oncology; Kiniksa Pharmaceuticals; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; CSL Behring; Alexion Pharmaceuticals; Gilead Sciences; Sanofi; GlaxoSmithKline; National Heart, Lung, and Blood Institute; Pfizer; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Celgene; InflaRx; University of Washington","keywords":"Neutrophil extracellular traps; Microscopic polyangiitis; Vasculitis; Granulomatosis with polyangiitis; Giant cell arteritis; Antibody; Anti-neutrophil cytoplasmic antibody; Medicine; Platelet; Immunology; Autoantibody; Arteritis; Gastroenterology; Internal medicine; Inflammation; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001369767,0.0004414369,0.001125385,0.0005153124,0.0003439298,0.00003665653,0.0004457217,0.001117948,0.0002594856],"category_scores_gemma":[0.0004391668,0.000421602,0.0002850286,0.0008199677,0.0006219842,0.0003668724,0.0003599535,0.001303283,0.001827524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006786615,"about_ca_system_score_gemma":0.0000651599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005178653,"about_ca_topic_score_gemma":0.00004890802,"domain_scores_codex":[0.9951316,0.001367107,0.001397974,0.0008631027,0.00007464356,0.001165584],"domain_scores_gemma":[0.9981011,0.0007656559,0.0003698362,0.000571278,0.0001269363,0.00006518792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000256681,0.0006931276,0.008509204,0.00003399139,0.0004961482,0.0003962707,0.0003530667,0.000008090075,0.9751648,0.00724549,0.001059819,0.005783314],"study_design_scores_gemma":[0.02486691,0.002549315,0.7552938,0.0003109072,0.0003263364,0.0005681184,0.001428189,0.0002962212,0.1470363,0.006813329,0.05889741,0.00161311],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911814,0.004332993,0.0002739852,0.001441432,0.001663116,0.0005038956,0.0001024579,0.0003477553,0.0001529139],"genre_scores_gemma":[0.9881106,0.009265171,0.00003809369,0.0003862587,0.00006971954,0.00005483818,0.001072561,0.00005686545,0.0009458972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8281285,"threshold_uncertainty_score":0.9998236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190783045646978,"score_gpt":0.3107628428307833,"score_spread":0.2788550123743135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}