{"id":"W4323075798","doi":"10.1016/j.clim.2023.109274","title":"Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis","year":2023,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; McMaster University","funders":"National Center for Advancing Translational Sciences; National Eye Institute; National Center for Research Resources; EMD Serono; Genentech; National Institutes of Health; Sierra Oncology; Kiniksa Pharmaceuticals; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; CSL Behring; Alexion Pharmaceuticals; Gilead Sciences; Sanofi; GlaxoSmithKline; National Heart, Lung, and Blood Institute; Pfizer; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Celgene; InflaRx; University of Washington","keywords":"Neutrophil extracellular traps; Microscopic polyangiitis; Vasculitis; Granulomatosis with polyangiitis; Giant cell arteritis; Antibody; Anti-neutrophil cytoplasmic antibody; Medicine; Platelet; Immunology; Autoantibody; Arteritis; Gastroenterology; Internal medicine; Inflammation; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000875839,0.0003530636,0.0002990151,0.000670972,0.0002811551,0.0003637529,0.0003163913,0.0008745505,0.001994118],"category_scores_gemma":[0.0009343651,0.0002399326,0.0002596509,0.0002366878,0.0003843941,0.0003900052,0.0003222675,0.000789017,0.0002258455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002899327,"about_ca_system_score_gemma":0.0002466396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005144662,"about_ca_topic_score_gemma":0.000445026,"domain_scores_codex":[0.9996605,0.0001207799,0.00003414504,0.00003627663,0.00007548106,0.00007276214],"domain_scores_gemma":[0.9994544,0.0001580722,0.0001311251,0.00003948331,0.00005012925,0.0001666366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05486182,0.003610763,0.1986135,0.001598809,0.0004286586,0.1054423,0.001336619,0.001000522,0.5665887,0.003687145,0.002197883,0.06063333],"study_design_scores_gemma":[0.001219446,0.01111791,0.7046034,0.000114793,0.0004469404,0.1284322,0.0006762237,0.007715473,0.1388537,0.001426231,0.005326584,0.00006695244],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951156,0.001925219,0.0009031931,0.00006284643,0.00003720716,0.00005258874,0.00006955863,0.00002201552,0.001811642],"genre_scores_gemma":[0.9992261,0.0001489356,0.0001919305,0.00002088683,0.00002507976,0.00001113815,0.00005332067,0.00000117911,0.000321425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001994118,"threshold_uncertainty_score":0.006671011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190783045646978,"score_gpt":0.3107628428307833,"score_spread":0.2788550123743135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}