{"id":"W4323294018","doi":"10.1128/aac.01525-22","title":"Antimicrobial Activity of Gepotidacin Tested against Escherichia coli and Staphylococcus saprophyticus Isolates Causing Urinary Tract Infections in Medical Centers Worldwide (2019 to 2020)","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Urinary Tract Infections Management","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biomedical Advanced Research and Development Authority; Medical Center, University of Rochester; Allergan; National Institutes of Health; Shionogi; Astellas Pharma; North Bristol NHS Trust; University of Queensland; bioMérieux; Amplyx; University of North Texas; National University of Singapore; Université de Sherbrooke; Medpace; University of Rochester; GlaxoSmithKline; Cidara Therapeutics; Tufts Medical Center; Nabriva Therapeutics; Wayne State University; Meiji Seika Pharma; Pfizer","keywords":"Staphylococcus saprophyticus; Urinary system; Microbiology; Antimicrobial; Escherichia coli; Medicine; Staphylococcus aureus; Staphylococcus; Biology; Internal medicine; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002616738,0.0003001938,0.000507284,0.0004959916,0.0001478609,0.00004784284,0.00007622893,0.0001515846,0.00008531062],"category_scores_gemma":[0.00004429222,0.0002926089,0.0000994231,0.001057766,0.0001483648,0.0001673033,0.0001253353,0.0003326215,0.00001455728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008951379,"about_ca_system_score_gemma":0.00009185261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004500296,"about_ca_topic_score_gemma":0.00006635024,"domain_scores_codex":[0.9983876,0.00006891726,0.0004228639,0.0004815957,0.000193462,0.0004455891],"domain_scores_gemma":[0.999248,0.00007732126,0.0001361085,0.0002559285,0.00005997996,0.0002226255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001177131,0.01496667,0.4065984,0.000636274,0.0004519215,0.001076008,0.001271632,0.0002970742,0.5318638,0.00000601177,0.0234371,0.01821797],"study_design_scores_gemma":[0.005623498,0.001911979,0.964018,0.0007597397,0.00009728825,0.0002641655,0.00006647612,0.001132497,0.01851802,0.000004703122,0.007128073,0.0004755796],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912038,0.00001798934,0.00007481605,0.007194893,0.0002368173,0.0009330284,0.00003356053,0.0001099396,0.0001951302],"genre_scores_gemma":[0.993948,0.001808592,0.000232253,0.003554363,0.0001065376,0.00001430724,0.00003097882,0.00005152472,0.0002533811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5574196,"threshold_uncertainty_score":0.9999526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140255023564004,"score_gpt":0.2703985604463942,"score_spread":0.2589960102107542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}