{"id":"W4323294993","doi":"10.1128/spectrum.03853-22","title":"Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and <i>In Vivo</i> Potency against Polymicrobial Sepsis","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, India; Academia Sinica; Public Health Agency of Canada; Ministry of Science and Technology","keywords":"Potency; In vivo; Antimicrobial; In vitro; Microbiology; Biology; Sepsis; Peptide; Pharmacology; Antimicrobial peptides; Toxicity; Chemistry; Medicine; Immunology; Biochemistry; Biotechnology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000236417,0.0004449859,0.0002995133,0.0002092511,0.0001094393,0.0004575688,0.0002851654,0.0003362916,0.0009542169],"category_scores_gemma":[0.000225734,0.0001664294,0.0002696256,0.000154993,0.0001840241,0.0003473991,0.0002617043,0.0005112409,0.0003506304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751476,"about_ca_system_score_gemma":0.0002398423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001631934,"about_ca_topic_score_gemma":0.0002944721,"domain_scores_codex":[0.9998864,0.00002328425,0.00001134046,0.00001701986,0.00003168999,0.00003026012],"domain_scores_gemma":[0.9999036,0.00001309141,0.00003365147,0.000004944499,0.0000156088,0.0000291593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003909112,0.0001451901,0.000207986,0.0001340999,0.00002249955,0.0002166919,0.00002654285,0.003621612,0.9852223,0.0004723108,0.0001372205,0.009402742],"study_design_scores_gemma":[0.0002410068,0.003133425,0.001048051,0.00002728318,0.00005150961,0.0004674953,0.00003010624,0.005693222,0.9814864,0.0002539719,0.007541057,0.00002656874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873006,0.001914581,0.008177276,0.0001166596,0.00004507994,0.0001581913,0.0001929467,0.00007645924,0.002018183],"genre_scores_gemma":[0.9822041,0.001711563,0.01450301,0.0001231636,0.00001773334,0.00009184898,0.0002029342,0.00002041545,0.001125282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009542169,"threshold_uncertainty_score":0.003192127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244989741665422,"score_gpt":0.2365484370649519,"score_spread":0.2240985396482977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}