{"id":"W4323295151","doi":"10.1158/0008-5472.can-22-2433","title":"LSD1 Inhibition Disrupts Super-Enhancer–Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; University of Massachusetts Boston; U.S. Department of Defense","keywords":"Prostate cancer; Cancer research; Coactivator; Corepressor; Androgen receptor; Enzalutamide; Enhancer; BRD4; EZH2; Cancer; Histone; Biology; Androgen deprivation therapy; Epigenetics; FOXA1; Transcription factor; Medicine; Nuclear receptor; Bromodomain; Breast cancer; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006328648,0.0001382721,0.0001288223,0.0001851916,0.0001632264,0.00006932472,0.000133341,0.0001460045,0.0000924737],"category_scores_gemma":[0.00004143592,0.000138547,0.00006965438,0.0007349995,0.0001471419,0.00001463139,0.00006157596,0.0002412035,0.00002744647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001654834,"about_ca_system_score_gemma":0.0005193453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008867917,"about_ca_topic_score_gemma":0.008924108,"domain_scores_codex":[0.9980208,0.0001739654,0.0002736203,0.0004907603,0.0004977281,0.0005431573],"domain_scores_gemma":[0.9993078,0.00001866828,0.00003904689,0.0002239824,0.0002958418,0.0001147024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002045427,0.00006073082,0.008483115,0.00005650665,0.00002048048,0.00001178453,0.0004175925,0.00104821,0.9790496,0.00007255796,0.0003629597,0.01021191],"study_design_scores_gemma":[0.001377002,0.0005102631,0.05951676,0.0001405635,0.00001155878,0.000001048411,0.0004472536,0.0002888671,0.9097273,0.0007557236,0.02688718,0.000336522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941816,0.003852427,0.0000305111,0.00074883,0.0001698711,0.0006803867,0.0001269628,0.00002201674,0.0001873806],"genre_scores_gemma":[0.9921071,0.00410842,0.00005977944,0.00001829184,0.0003524037,0.001303316,0.0006637665,0.00003439132,0.001352531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06932236,"threshold_uncertainty_score":0.5649784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1109575234202194,"score_gpt":0.4066697140039471,"score_spread":0.2957121905837277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}