{"id":"W4323295151","doi":"10.1158/0008-5472.can-22-2433","title":"LSD1 Inhibition Disrupts Super-Enhancer–Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; University of Massachusetts Boston; U.S. Department of Defense","keywords":"Prostate cancer; Cancer research; Coactivator; Corepressor; Androgen receptor; Enzalutamide; Enhancer; BRD4; EZH2; Cancer; Histone; Biology; Androgen deprivation therapy; Epigenetics; FOXA1; Transcription factor; Medicine; Nuclear receptor; Bromodomain; Breast cancer; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000933007,0.0002637593,0.0002769391,0.0002815859,0.0001164952,0.0001949114,0.0001679744,0.0001301268,0.001039649],"category_scores_gemma":[0.00005040251,0.0001357748,0.0002895374,0.0001921967,0.0001554484,0.00007238358,0.0001241219,0.0005088935,0.0002121253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964225,"about_ca_system_score_gemma":0.000368359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002096375,"about_ca_topic_score_gemma":0.003932731,"domain_scores_codex":[0.9999024,0.000009417586,0.000007273697,0.00001877765,0.00003347088,0.00002870248],"domain_scores_gemma":[0.9999501,0.000005475656,0.00001200814,0.000005770222,0.000004341691,0.00002232978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499686,0.0000522449,0.0001454544,0.00002822598,0.000005563656,0.00002753704,0.000007226493,0.0001322165,0.9982702,0.00003488305,0.00007684251,0.001069595],"study_design_scores_gemma":[0.00003001318,0.0008480831,0.005826567,0.000003382145,0.00002132302,0.0001490521,0.00002491844,0.001732897,0.9894048,0.00002449728,0.001927024,0.000007465195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960397,0.00105532,0.001071162,0.00006186852,0.00002836807,0.00002979403,0.0007738562,0.0001946652,0.000745228],"genre_scores_gemma":[0.9954164,0.0005537632,0.001066735,0.00004513696,0.000004713648,0.00002892258,0.0009134849,0.00002312108,0.001947634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002096375,"threshold_uncertainty_score":0.004168332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1109575234202194,"score_gpt":0.4066697140039471,"score_spread":0.2957121905837277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}