{"id":"W4323308419","doi":"10.1055/a-2047-8301","title":"Re-evaluation of P-Chiral, N-Phosphoryl Sulfonamide Brønsted Acids in the Asymmetric Synthesis of 1,2,3,4-Tetrahydroquinoline-2-carboxylate Esters via Biomimetic Transfer Hydrogenation","year":2023,"lang":"en","type":"article","venue":"Synlett","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Peptidomimetic; Transfer hydrogenation; Sulfonamide; Bioisostere; Enantioselective synthesis; Combinatorial chemistry; Quinoline; Asymmetric hydrogenation; Catalysis; Phosphonate; Organic chemistry; Stereochemistry; Chemical synthesis; Peptide; Ruthenium","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00272517,0.0002814551,0.0005040327,0.001496779,0.00007191391,0.00002245322,0.000575421,0.0002527204,0.0002280639],"category_scores_gemma":[0.001006082,0.0002454237,0.0003318253,0.007157272,0.0001400257,0.0001557433,0.00004410579,0.0002250815,0.00005853378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001679531,"about_ca_system_score_gemma":0.0001112699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002094493,"about_ca_topic_score_gemma":0.00006038621,"domain_scores_codex":[0.9961889,0.0002784333,0.00102819,0.0004509214,0.001663848,0.0003896646],"domain_scores_gemma":[0.9978827,0.0008017438,0.0002750093,0.0007111841,0.0002608867,0.00006843702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00035391,0.001583002,0.02340605,0.001273039,0.001692372,0.00006224768,0.006223124,0.01554142,0.4893443,0.001093268,0.0006563065,0.4587709],"study_design_scores_gemma":[0.001377483,0.00004031669,0.00594488,0.0001023835,0.0006678355,0.00000684846,0.001201308,0.08130864,0.9083427,0.0005015388,0.0001550601,0.0003509742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874398,0.0004395416,0.0002740559,0.0004413051,0.00008440339,0.0003231633,0.00006752415,0.00009291092,0.01083731],"genre_scores_gemma":[0.9992858,0.0001451127,0.00003444801,0.00006475332,0.00003552299,0.0001196098,0.0001775895,0.00004364851,0.00009356243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4584199,"threshold_uncertainty_score":0.9999998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486126704954821,"score_gpt":0.2681445375419131,"score_spread":0.2432832704923649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}