{"id":"W4323308419","doi":"10.1055/a-2047-8301","title":"Re-evaluation of P-Chiral, N-Phosphoryl Sulfonamide Brønsted Acids in the Asymmetric Synthesis of 1,2,3,4-Tetrahydroquinoline-2-carboxylate Esters via Biomimetic Transfer Hydrogenation","year":2023,"lang":"en","type":"article","venue":"Synlett","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Peptidomimetic; Transfer hydrogenation; Sulfonamide; Bioisostere; Enantioselective synthesis; Combinatorial chemistry; Quinoline; Asymmetric hydrogenation; Catalysis; Phosphonate; Organic chemistry; Stereochemistry; Chemical synthesis; Peptide; Ruthenium","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004457337,0.0004300776,0.0002044188,0.0001601231,0.0001259906,0.0001859968,0.0002759116,0.0003651296,0.0007650921],"category_scores_gemma":[0.0003389684,0.0001074747,0.0001861205,0.0001367406,0.0002222881,0.0003407289,0.0002362187,0.0003407057,0.0003613797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428072,"about_ca_system_score_gemma":0.0003205469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005812334,"about_ca_topic_score_gemma":0.001327031,"domain_scores_codex":[0.9997954,0.00004798863,0.00001693212,0.00002871277,0.00006688262,0.00004419963],"domain_scores_gemma":[0.9998795,0.00001994517,0.00002901048,0.00001258524,0.00003141864,0.00002753376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001746858,0.00006661288,0.00007596736,0.0001411667,0.00001092559,0.0001199309,0.00004341869,0.0004631571,0.9945332,0.0002757104,0.00007021251,0.004025075],"study_design_scores_gemma":[0.00002579895,0.0006948536,0.0002391288,0.000004341512,0.000008721777,0.00006578989,0.00001408646,0.0007736914,0.9966461,0.00003347604,0.001487545,0.000006501917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988646,0.001578483,0.00458063,0.0000917154,0.00004864872,0.00008235903,0.000122942,0.00005120284,0.00479793],"genre_scores_gemma":[0.9956036,0.0007676636,0.002321986,0.00002027883,0.000007470131,0.00001646366,0.00007790502,0.00001189705,0.001172747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007650921,"threshold_uncertainty_score":0.002559483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486126704954821,"score_gpt":0.2681445375419131,"score_spread":0.2432832704923649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}