{"id":"W4323309098","doi":"10.1053/j.ajkd.2022.12.015","title":"Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial","year":2023,"lang":"en","type":"article","venue":"American Journal of Kidney Diseases","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; University of British Columbia","funders":"Sydney Medical School; Medical Research Council; School of Medicine, Indiana University; School of Medicine, Stanford University; George Institute for Global Health; National Health and Medical Research Council; Peking University; York University; Universitair Medisch Centrum Groningen; Brigham and Women's Hospital; University College London; University of Toronto; Janssen Research and Development; Rijksuniversiteit Groningen; University of New South Wales; Peking University First Hospital; NYU Langone Medical Center; University of Chicago Medicine; Imperial College London","keywords":"Medicine; Canagliflozin; Kidney disease; Internal medicine; Creatinine; Placebo; Renal function; Population; Randomized controlled trial; Diabetes mellitus; Endocrinology; Type 2 diabetes; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02895033,0.002542504,0.007414042,0.0008924638,0.0006556151,0.002281082,0.001290216,0.002255228,0.009610795],"category_scores_gemma":[0.03771921,0.0007613422,0.009821686,0.0009677255,0.001904264,0.002032569,0.0008608625,0.002886456,0.0006206426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008419762,"about_ca_system_score_gemma":0.001942246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005230331,"about_ca_topic_score_gemma":0.0007557437,"domain_scores_codex":[0.9779137,0.0156669,0.001557832,0.002083724,0.001575278,0.001202649],"domain_scores_gemma":[0.9698853,0.02048589,0.003773288,0.00327321,0.001415997,0.001166319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9772887,0.0009212072,0.003377172,0.001144423,0.01037481,0.0000719672,0.00004839318,0.0004191715,0.0005498288,0.0002717459,0.0009100009,0.00462258],"study_design_scores_gemma":[0.8864541,0.05590546,0.02059494,0.0002585604,0.02646204,0.000133114,0.00007106803,0.003567713,0.001437305,0.001673272,0.00334178,0.0001006996],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360155,0.01491395,0.00743824,0.00186544,0.003409307,0.0237049,0.005766456,0.0004670178,0.006419325],"genre_scores_gemma":[0.9675131,0.001236133,0.005620015,0.001365888,0.001444028,0.01752285,0.002252986,0.0000853723,0.002959686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02895033,"threshold_uncertainty_score":0.1531059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228824683378209,"score_gpt":0.3022892696714148,"score_spread":0.2900010228376327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}