{"id":"W4323310092","doi":"10.1101/2023.03.01.23286492","title":"Leisure time sedentary behaviour and risks of breast, colorectal, and prostate cancer: A Mendelian randomization analysis","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; World Cancer Research Fund; National Center for Advancing Translational Sciences; Medical Research Council; Junta de Castilla y León; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; NordForsk; Vetenskapsrådet; Stockholms Läns Landsting; Cancerfonden; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Generalitat de Catalunya; Hellenic Health Foundation; Fundación Científica Asociación Española Contra el Cáncer; Swedish Cancer Foundation; Bundesministerium für Bildung und Forschung; Centre International de Recherche sur le Cancer; Grantová Agentura České Republiky; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; Chonnam National University Hwasun Hospital; Government of Canada; Centres de Recerca de Catalunya; Damon Runyon Cancer Research Foundation; Gray Foundation; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Cancer Research UK; Innovative Medicines Initiative; American Cancer Society; Institut Gustave-Roussy; Chonnam National University; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Medicine; Breast cancer; Prostate cancer; Colorectal cancer; Oncology; Confounding; Genome-wide association study; Internal medicine; Epidemiology; Cancer; Gynecology; Demography; Single-nucleotide polymorphism; Genetics; Genotype; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04224269,0.001681857,0.003255345,0.002361132,0.0007181626,0.001177999,0.001899413,0.001624752,0.006014797],"category_scores_gemma":[0.06957015,0.0009347078,0.007975411,0.002474314,0.0008652247,0.0009502446,0.0009469223,0.001175712,0.0004462414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009574216,"about_ca_system_score_gemma":0.001704723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005784685,"about_ca_topic_score_gemma":0.002607358,"domain_scores_codex":[0.9476889,0.0392369,0.002365585,0.006310296,0.003516455,0.0008818856],"domain_scores_gemma":[0.9667621,0.02406815,0.002931084,0.004784584,0.001118044,0.0003360781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0741571,0.001620447,0.4188846,0.005024017,0.1753778,0.008629156,0.001706775,0.03666519,0.01773042,0.0493545,0.01347828,0.1973718],"study_design_scores_gemma":[0.02607901,0.01465307,0.2633963,0.0007420346,0.1098119,0.01073168,0.0003920073,0.486227,0.005851831,0.06048793,0.02091486,0.0007124452],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4716895,0.008802472,0.5062217,0.001405325,0.0005764234,0.003593831,0.002869645,0.001914355,0.002926823],"genre_scores_gemma":[0.864328,0.001282927,0.1270331,0.0005424956,0.0001450661,0.003272067,0.001361113,0.0002142785,0.001821],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04224269,"threshold_uncertainty_score":0.2234034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02249456577637899,"score_gpt":0.3068976444182195,"score_spread":0.2844030786418406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}