{"id":"W4323311978","doi":"10.1016/j.celrep.2023.112206","title":"Sharp cell-type-identity changes differentiate the retrosplenial cortex from the neocortex","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Institute for Military and Veteran Health Research; University of British Columbia; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Howard Hughes Medical Institute","keywords":"Retrosplenial cortex; Neocortex; Chromatin structure remodeling (RSC) complex; Cell type; Neuroscience; Biology; Transcriptome; Cortex (anatomy); Cerebral cortex; Cell; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002655903,0.000204899,0.0001681109,0.00001927534,0.0002845051,0.0001125706,0.0003411208,0.0001673989,0.0001356175],"category_scores_gemma":[0.00005314553,0.0001292206,0.0001471214,0.0001765832,0.00009350567,0.000005528401,0.0001920697,0.0001876612,0.00005731521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001107814,"about_ca_system_score_gemma":0.00006263027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004876315,"about_ca_topic_score_gemma":0.0006385652,"domain_scores_codex":[0.9985682,0.00007118548,0.0002779266,0.0004873942,0.0002627903,0.0003325087],"domain_scores_gemma":[0.9987817,0.00003573074,0.0001906416,0.0008415228,0.00007563126,0.00007478479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004082682,0.00005496144,0.03699235,0.00001408132,0.0000387054,0.000110958,0.0001572159,0.000009587204,0.9420959,0.00000670196,0.02000353,0.0004751948],"study_design_scores_gemma":[0.0005351006,0.0002150789,0.2761778,0.00002247606,0.0001694702,0.0000400699,0.0001785945,0.0002007138,0.5692651,0.000740756,0.1519616,0.0004932596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942299,0.000847107,0.0001434065,0.0003761401,0.002213741,0.000277859,0.0000323334,0.0000536515,0.001825821],"genre_scores_gemma":[0.9911447,0.0008023481,0.00001865644,0.0004521085,0.0008857771,0.00002104012,0.000586364,0.00003970443,0.006049307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3728308,"threshold_uncertainty_score":0.5269465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665946967271578,"score_gpt":0.2327958170214284,"score_spread":0.2161363473487126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}