{"id":"W4323312607","doi":"10.3390/cimb45030135","title":"The Landscape and Therapeutic Targeting of BRCA1, BRCA2 and Other DNA Damage Response Genes in Pancreatic Cancer","year":2023,"lang":"en","type":"review","venue":"Current Issues in Molecular Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Sault Area Hospital","funders":"","keywords":"Pancreatic cancer; BRCA2 Protein; Cancer research; Gene; DNA repair; Biology; RAD51; PARP inhibitor; Germline mutation; Somatic cell; Ovarian cancer; Cancer; Mutation; Prostate cancer; Homologous recombination; Genetics; Poly ADP ribose polymerase; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005322029,0.000605224,0.001040644,0.001635485,0.0001986346,0.0006445018,0.0007863029,0.0009203079,0.00225963],"category_scores_gemma":[0.0004453084,0.0002250347,0.0005401256,0.001357378,0.0003515862,0.0009788162,0.0004992751,0.002402712,0.001209851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004839194,"about_ca_system_score_gemma":0.0005113181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005365839,"about_ca_topic_score_gemma":0.001298662,"domain_scores_codex":[0.9998481,0.00002989739,0.00002000686,0.00002190308,0.00006434003,0.00001563836],"domain_scores_gemma":[0.9998374,0.00006986768,0.0000287088,0.000005317715,0.00004053249,0.00001810142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001012461,0.0001456483,0.0001524447,0.01288547,0.00009125524,0.0002402172,0.0000547397,0.0005595256,0.002824711,0.002996532,0.03012464,0.9498236],"study_design_scores_gemma":[0.00004059269,0.0002459681,0.001202927,0.004058742,0.0001251356,0.001839188,0.00005774597,0.0001794193,0.0008290106,0.00194186,0.9894614,0.00001808264],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001272356,0.9988328,0.000087375,0.000223244,0.0001262772,0.000003436663,0.000008328301,0.000006341484,0.0005849801],"genre_scores_gemma":[0.0005914281,0.9985074,0.0001540776,0.0002049304,0.000115816,0.000005179192,0.00001929415,0.000001210476,0.0004005224],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00225963,"threshold_uncertainty_score":0.00755924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06945523662706116,"score_gpt":0.4431509062315858,"score_spread":0.3736956696045247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}