{"id":"W4323318843","doi":"10.3390/cells12050798","title":"Transcriptional Response to Hypoxia: The Role of HIF-1-Associated Co-Regulators","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hellenic Foundation for Research and Innovation; Bodossaki Foundation","keywords":"Cellular adaptation; Chromatin; Biology; Transcription factor; Transcriptional regulation; Hypoxia-inducible factors; Cell biology; Hypoxia (environmental); Regulation of gene expression; Gene; Gene expression; Promoter; Phenotype; Adaptive response; Computational biology; Genetics; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006213476,0.00030661,0.0007785069,0.0001009234,0.00007700452,0.00001782745,0.0004492879,0.0004269861,0.00005643037],"category_scores_gemma":[0.0001100505,0.0002283539,0.0006515046,0.0003182337,0.00009533469,0.000001423193,0.00007320493,0.0001778122,0.0001392516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003008362,"about_ca_system_score_gemma":0.0004489712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002143193,"about_ca_topic_score_gemma":0.00002386414,"domain_scores_codex":[0.9982635,0.0003229669,0.000460378,0.000409803,0.0002404901,0.0003028207],"domain_scores_gemma":[0.9989627,0.00008492075,0.0002193185,0.0005361265,0.00008300673,0.0001139415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000352991,0.0001667571,0.000001721589,0.0016668,0.001135298,0.000002643804,0.0002113897,0.00001273559,0.5701506,0.0001406635,0.07569937,0.350459],"study_design_scores_gemma":[0.0001791923,0.00007115347,0.00003442694,0.0004655487,0.0003269972,0.000003967566,0.00002856147,4.210885e-7,0.008009167,0.00002384518,0.9906182,0.0002385684],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00209786,0.9947494,0.000006318012,0.00003128232,0.001231952,0.0006160989,0.0008509509,0.0000184198,0.0003977418],"genre_scores_gemma":[0.0001824386,0.991006,0.00002558579,0.00007858224,0.0009579209,0.00009830525,0.0003780963,0.00007920284,0.007193883],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9149188,"threshold_uncertainty_score":0.9312003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209654889252085,"score_gpt":0.2946605226688124,"score_spread":0.2725639737762916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}