{"id":"W4323318843","doi":"10.3390/cells12050798","title":"Transcriptional Response to Hypoxia: The Role of HIF-1-Associated Co-Regulators","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hellenic Foundation for Research and Innovation; Bodossaki Foundation","keywords":"Cellular adaptation; Chromatin; Biology; Transcription factor; Transcriptional regulation; Hypoxia-inducible factors; Cell biology; Hypoxia (environmental); Regulation of gene expression; Gene; Gene expression; Promoter; Phenotype; Adaptive response; Computational biology; Genetics; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003670825,0.000698707,0.0009623367,0.00118776,0.000223009,0.0008659749,0.0007383617,0.0008464637,0.001749683],"category_scores_gemma":[0.0004117406,0.0001980512,0.0002912884,0.001621948,0.0005382033,0.0009346321,0.0005883485,0.001698585,0.002002737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007356629,"about_ca_system_score_gemma":0.0007675912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007214188,"about_ca_topic_score_gemma":0.0008790805,"domain_scores_codex":[0.9998653,0.00002317826,0.00001515201,0.00003069853,0.00004907829,0.00001658408],"domain_scores_gemma":[0.9998672,0.00005268618,0.00001773842,0.000004663631,0.00004086894,0.0000167487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009945888,0.00004896226,0.0002059211,0.01439795,0.00006755078,0.0002789808,0.0001078274,0.0005895144,0.007874125,0.009237347,0.03819796,0.9288943],"study_design_scores_gemma":[0.000007280681,0.00004792824,0.0005921529,0.001070577,0.00003169003,0.0008616772,0.00003797772,0.00005836258,0.0008271529,0.002058183,0.9943967,0.00001040448],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001022015,0.9981605,0.0001988998,0.0002635391,0.0002435944,0.000002760636,0.00001460567,0.000007692465,0.00100627],"genre_scores_gemma":[0.0007239084,0.998102,0.0001600119,0.0001830074,0.0001797378,0.000005182508,0.00002820075,0.000002027712,0.0006158502],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001749683,"threshold_uncertainty_score":0.005853295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209654889252085,"score_gpt":0.2946605226688124,"score_spread":0.2725639737762916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}