{"id":"W4323322156","doi":"10.1007/s10689-023-00329-0","title":"Hereditary acute myeloid leukemia associated with C-terminal CEBPA germline variants","year":2023,"lang":"en","type":"review","venue":"Familial Cancer","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"CEBPA; Germline; Myeloid leukemia; Germline mutation; Myeloid; Leukemia; Acute leukemia; Medicine; Penetrance; Cancer research; Biology; Genetics; Mutation; Internal medicine; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006810838,0.001167615,0.00411219,0.0006308208,0.0002162632,0.00006371739,0.0007577913,0.001267957,0.0008688243],"category_scores_gemma":[0.0003624785,0.0008467506,0.0007803968,0.001980982,0.0003519614,0.0001642222,0.0003960231,0.002874922,0.00108035],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.008206048,"about_ca_system_score_gemma":0.01456987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001373596,"about_ca_topic_score_gemma":0.000486622,"domain_scores_codex":[0.9940403,0.0003326826,0.00117676,0.001399983,0.001559776,0.001490576],"domain_scores_gemma":[0.9966711,0.0004890678,0.0005939869,0.001123427,0.0004712447,0.0006511048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007975657,0.000153087,0.0000811723,0.0199283,0.008851574,0.02614323,0.0001276261,0.000006147405,0.00001204176,0.00001438031,0.189098,0.7547869],"study_design_scores_gemma":[0.003232321,0.0007135983,0.0009973416,0.0406513,0.008910414,0.001208128,0.00002797991,0.0001562792,0.000003076398,0.00001216451,0.9429995,0.001087852],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006675505,0.9892179,0.00001669687,0.0001907366,0.00166144,0.002922794,0.003063722,0.0005656056,0.001693604],"genre_scores_gemma":[0.00001032844,0.9529233,0.0001939051,0.0004958944,0.004276704,0.001128872,0.003074163,0.0005160712,0.03738078],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7539016,"threshold_uncertainty_score":0.9996974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06724940709402184,"score_gpt":0.3758539923435198,"score_spread":0.308604585249498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}