{"id":"W4323322156","doi":"10.1007/s10689-023-00329-0","title":"Hereditary acute myeloid leukemia associated with C-terminal CEBPA germline variants","year":2023,"lang":"en","type":"review","venue":"Familial Cancer","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"CEBPA; Germline; Myeloid leukemia; Germline mutation; Myeloid; Leukemia; Acute leukemia; Medicine; Penetrance; Cancer research; Biology; Genetics; Mutation; Internal medicine; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004153977,0.0008756529,0.00129231,0.002312062,0.0001734983,0.000645993,0.0006218671,0.0007273323,0.003312316],"category_scores_gemma":[0.001120938,0.0002203694,0.0004574034,0.002160844,0.0002956415,0.000586533,0.0005224999,0.0009795158,0.0008209904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005668884,"about_ca_system_score_gemma":0.000941358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266111,"about_ca_topic_score_gemma":0.002376917,"domain_scores_codex":[0.9998146,0.00002896298,0.00003602797,0.00004442408,0.00005863106,0.00001742717],"domain_scores_gemma":[0.9996337,0.0002046074,0.00006596722,0.00001020183,0.0000562215,0.00002919725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001166632,0.00002796437,0.0007456561,0.01403055,0.0003120129,0.0007613501,0.00003263264,0.0003450573,0.001361411,0.001792285,0.04306252,0.9374118],"study_design_scores_gemma":[0.00009276139,0.00006922224,0.002671566,0.008718088,0.001415264,0.00732759,0.00006704926,0.0001428172,0.0007377768,0.001777044,0.9769521,0.00002864484],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000155131,0.9982829,0.0001252755,0.0002611474,0.0001767037,0.000002750263,0.00003554541,0.000008417746,0.0009521489],"genre_scores_gemma":[0.001607138,0.9968843,0.0002659859,0.0003573327,0.0002507883,0.000005207348,0.00008045069,0.000002174965,0.0005466729],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003312316,"threshold_uncertainty_score":0.0110808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06724940709402184,"score_gpt":0.3758539923435198,"score_spread":0.308604585249498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}