{"id":"W4323322251","doi":"10.1182/blood.2022018309","title":"Natural killer cell memory precedes HLH in monozygotic twins discordant for chronic active Epstein-Barr virus disease","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Institute of Molecular and Cell Biology; National University of Singapore; Agency for Science, Technology and Research; Duke-NUS Medical School","keywords":"Immunology; Hemophagocytic lymphohistiocytosis; Biology; Perforin; Virus; Cytokine; Immune system; Disease; Medicine; CD8; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002400352,0.0004311627,0.0003819655,0.001050972,0.0007022842,0.0004694726,0.0003600175,0.0006345306,0.002077021],"category_scores_gemma":[0.001440165,0.0003727747,0.0003431009,0.000304994,0.0005822062,0.0003110897,0.0005829447,0.0007566044,0.0002212765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003642099,"about_ca_system_score_gemma":0.0002284474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001579723,"about_ca_topic_score_gemma":0.001613906,"domain_scores_codex":[0.9996729,0.00005563751,0.00004002905,0.0001005613,0.00005726355,0.00007352267],"domain_scores_gemma":[0.999524,0.00009361831,0.0001462764,0.00003132016,0.00003835494,0.000166444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002765525,0.0004750412,0.7154112,0.0001248501,0.0001221196,0.2185465,0.0033368,0.0001853477,0.04383756,0.001323456,0.0009014037,0.01297014],"study_design_scores_gemma":[0.00009387275,0.001324816,0.5832796,0.00007771406,0.0001148905,0.4040792,0.001453226,0.0009258168,0.006303983,0.0006859223,0.001619283,0.00004167167],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990993,0.0001294534,0.0001183291,0.00007203808,0.00002067757,0.00001182598,0.00003464712,0.000005079348,0.0005086263],"genre_scores_gemma":[0.9994752,0.00009255629,0.0001235276,0.00004000892,0.00002046795,0.000004311759,0.00003735541,0.000003492138,0.0002031421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002077021,"threshold_uncertainty_score":0.006948292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022940570400396,"score_gpt":0.2361574049634045,"score_spread":0.2259279992594006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}