{"id":"W4323342633","doi":"10.1007/978-3-031-22468-3_7","title":"Healthy Brain Ageing and Longevity; the Harmony of Natural Products, APOE Polymorphism, and Melatonin","year":2023,"lang":"en","type":"book-chapter","venue":"Healthy ageing and longevity","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Melatonin; Longevity; Ageing; Neuroprotection; Apolipoprotein E; Biology; Alzheimer's disease; Healthy ageing; Internal medicine; Endocrinology; Disease; Medicine; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001706889,0.0006887537,0.001056484,0.0003303931,0.0009994701,0.000150788,0.0002691653,0.0004821782,0.00001673293],"category_scores_gemma":[0.0008829863,0.0005634355,0.0001296304,0.0002370089,0.001054465,0.0002372832,0.0004046466,0.001866437,0.000021609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009783119,"about_ca_system_score_gemma":0.0002978518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004550598,"about_ca_topic_score_gemma":0.0002528527,"domain_scores_codex":[0.9957535,0.0003601692,0.0008865319,0.001537348,0.0005960094,0.0008664913],"domain_scores_gemma":[0.9964762,0.001475332,0.0007203923,0.000786648,0.0000736742,0.0004677988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002458588,0.0003055765,0.00330479,0.0190733,0.0003519332,0.00500536,0.01946848,0.00001049388,0.01758299,0.5300919,0.01741632,0.3849303],"study_design_scores_gemma":[0.01096593,0.004313234,0.2783051,0.009601819,0.001155061,0.007220876,0.0007454148,0.00201443,0.01834553,0.01965974,0.6395376,0.008135269],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8330228,0.1005832,0.00002114543,0.04831874,0.002716548,0.003017084,0.0003298573,0.0004588994,0.01153163],"genre_scores_gemma":[0.919134,0.02053565,0.00006892881,0.005974942,0.0007913936,0.00003329253,0.00002055763,0.0001853036,0.05325591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6221213,"threshold_uncertainty_score":0.9996817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04479164776410324,"score_gpt":0.2707188096802211,"score_spread":0.2259271619161178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}