{"id":"W4323347664","doi":"10.1136/bmjopen-2022-063198","title":"Discontinuation of tofacitinib and TNF inhibitors in patients with rheumatoid arthritis: analysis of pooled data from two registries in Canada","year":2023,"lang":"en","type":"article","venue":"BMJ Open","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Pfizer Pharmaceuticals; F. Hoffmann-La Roche; Sanofi Genzyme; University of Toronto; Samsung; Celgene; Gilead Sciences; Celltrion; Sanofi; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Discontinuation; Rheumatoid arthritis; Tofacitinib; Internal medicine; Proportional hazards model; Cohort; Hazard ratio; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006217021,0.0007238532,0.001882124,0.004383869,0.0012262,0.001739439,0.001344943,0.0006307837,0.0008848888],"category_scores_gemma":[0.01398668,0.0006232374,0.003046007,0.01311171,0.0005553926,0.0004530907,0.001354543,0.0006318484,0.0001042726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01514184,"about_ca_system_score_gemma":0.02292608,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9362428,"about_ca_topic_score_gemma":0.9382548,"domain_scores_codex":[0.9922687,0.00159116,0.001126135,0.001351612,0.002438421,0.001224081],"domain_scores_gemma":[0.9810804,0.002312462,0.008305114,0.001424819,0.005561069,0.001316176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003092215,0.000009423831,0.9951677,0.00009496733,0.001650082,0.00004873232,0.0001119298,0.0001663962,0.00004064111,0.00002628495,0.0004235189,0.001951202],"study_design_scores_gemma":[0.00006587066,0.00004462298,0.9969224,0.0000889252,0.001295275,0.00009671878,0.0002452806,0.0005075895,0.00005041769,0.00001854548,0.0006456622,0.00001852087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741139,0.007842182,0.0006284938,0.0003194891,0.00002946141,0.0001400152,0.01579957,0.00003497104,0.001091931],"genre_scores_gemma":[0.9898778,0.002203351,0.0003929117,0.000111825,0.00002120179,0.00006719356,0.007079371,0.0000108669,0.0002355044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06375724,"threshold_uncertainty_score":0.1282654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04110418907347557,"score_gpt":0.336577244390545,"score_spread":0.2954730553170694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}