{"id":"W4323348324","doi":"10.1084/jem.20220170","title":"Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Fundación Canaria Instituto de Investigación Sanitaria de Canarias; Agencia Estatal de Investigación; Instituto de Salud Carlos III; National Center for Advancing Translational Sciences; HORIZON EUROPE Framework Programme; National Center for Research Resources; Universität Zürich; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Ministerio de Ciencia e Innovación; Fundación Mapfre; Else Kröner-Fresenius-Stiftung; European Commission; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Centres de Recerca de Catalunya; CSL Behring; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; National Science Foundation","keywords":"Pneumonia; Penetrance; Medicine; Population; Immunology; Atypical pneumonia; Internal medicine; Biology; Gene; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349054,0.0007417462,0.0004511222,0.0005939719,0.00053471,0.0002587422,0.0001814632,0.0003863281,0.002450511],"category_scores_gemma":[0.0006290669,0.0002984358,0.0002168143,0.0003037827,0.0004481184,0.0002379346,0.0004313016,0.0003117057,0.0002654233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001067818,"about_ca_system_score_gemma":0.00008208385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005679425,"about_ca_topic_score_gemma":0.0004754712,"domain_scores_codex":[0.9998181,0.0000508036,0.00001863773,0.00004624053,0.00002293963,0.00004340525],"domain_scores_gemma":[0.9997495,0.00004381795,0.0001190298,0.00002205163,0.00001713249,0.00004847527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001698006,0.0001909791,0.8858227,0.0000872154,0.0002148133,0.02855489,0.001018178,0.0002618293,0.07022752,0.0002854628,0.0005755898,0.0110628],"study_design_scores_gemma":[0.00004960686,0.0008728247,0.9232532,0.00002680513,0.0001181151,0.06976196,0.0006765397,0.000325872,0.003389044,0.0002520088,0.001250677,0.00002330265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994004,0.0001389167,0.0001588147,0.00001957278,0.000003239499,0.000004146394,0.00003857759,0.000007551869,0.0002288684],"genre_scores_gemma":[0.9994352,0.0001127572,0.00016579,0.00002521409,0.000009922093,0.000003948897,0.00006736781,0.000003299131,0.0001764383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002450511,"threshold_uncertainty_score":0.008197844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03052640594280187,"score_gpt":0.2989012670301731,"score_spread":0.2683748610873712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}