{"id":"W4323348324","doi":"10.1084/jem.20220170","title":"Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Fundación Canaria Instituto de Investigación Sanitaria de Canarias; Agencia Estatal de Investigación; Instituto de Salud Carlos III; National Center for Advancing Translational Sciences; HORIZON EUROPE Framework Programme; National Center for Research Resources; Universität Zürich; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Ministerio de Ciencia e Innovación; Fundación Mapfre; Else Kröner-Fresenius-Stiftung; European Commission; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Centres de Recerca de Catalunya; CSL Behring; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; National Science Foundation","keywords":"Pneumonia; Penetrance; Medicine; Population; Immunology; Atypical pneumonia; Internal medicine; Biology; Gene; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007206301,0.0001249603,0.0002535105,0.0002127279,0.0002387643,0.000006472505,0.0001927464,0.00005838114,0.0001261081],"category_scores_gemma":[0.0002236182,0.00006594668,0.00002452375,0.0002806001,0.0003330194,0.00008411303,0.00006068495,0.0001866331,0.00004344024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006445568,"about_ca_system_score_gemma":0.00005830729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004720858,"about_ca_topic_score_gemma":0.000008280584,"domain_scores_codex":[0.9990855,0.0002078374,0.0003314689,0.00008720781,0.00009251881,0.0001955015],"domain_scores_gemma":[0.9992732,0.0002318221,0.0002375534,0.0001439684,0.00005785942,0.00005552934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00154055,0.00002792356,0.0005395279,0.00000880939,0.00005842699,0.00002359314,0.02070557,0.00002301785,0.9733307,0.00003517929,0.003543064,0.0001636198],"study_design_scores_gemma":[0.006388682,0.006500898,0.0679706,0.0004301566,0.0001475237,0.002304245,0.1044899,0.00001311753,0.793056,0.00006349639,0.01838046,0.0002548927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878474,0.006724672,0.00005884978,0.004751399,0.0002561409,0.0002229034,0.000002043466,0.00002958941,0.0001069848],"genre_scores_gemma":[0.998271,0.0002288155,0.00001205494,0.0009166932,0.00005731137,0.000006230581,0.000007015087,0.00001097363,0.000489947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1802747,"threshold_uncertainty_score":0.2689228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03052640594280187,"score_gpt":0.2989012670301731,"score_spread":0.2683748610873712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}