{"id":"W4323348563","doi":"10.1016/j.jconrel.2023.03.002","title":"Protamine-mediated efficient transcellular and transmucosal delivery of proteins","year":2023,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Canada Foundation for Innovation","keywords":"Protamine; Transcellular; Adherens junction; Paracellular transport; Endocytosis; Chemistry; Insulin; Cell-penetrating peptide; Cell biology; Pharmacology; Peptide; Biochemistry; Medicine; Biology; Internal medicine; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041078,0.0003408341,0.0002144929,0.0001255028,0.0001708558,0.0003289657,0.0002364262,0.0004128689,0.0003648181],"category_scores_gemma":[0.0001530934,0.0001476642,0.0002204873,0.0001403375,0.000213544,0.0003820148,0.0002603055,0.0003879093,0.0002609155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003290695,"about_ca_system_score_gemma":0.0002351569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005889082,"about_ca_topic_score_gemma":0.0008882686,"domain_scores_codex":[0.9998593,0.00002423798,0.00001178503,0.00003491281,0.00003074631,0.00003895648],"domain_scores_gemma":[0.9999245,0.0000145676,0.00002816964,0.000009144595,0.00001188969,0.00001165301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000069401,0.000005094931,0.00001701723,0.00001998589,0.000002281116,0.00003929561,0.00001752861,0.00002971347,0.9988059,0.00009871061,0.00001893518,0.0008761993],"study_design_scores_gemma":[0.000004233171,0.00005463363,0.0002321076,0.00000101625,0.000004174615,0.00006422838,0.000003848073,0.0002120124,0.9988214,0.000007238929,0.0005927174,0.000002276054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855821,0.001702921,0.01085787,0.00008312168,0.00002684669,0.00004024465,0.0001331245,0.000088464,0.001485319],"genre_scores_gemma":[0.9914036,0.0008844072,0.004391121,0.00002757253,0.000006619439,0.00001991069,0.0001391562,0.00002813351,0.003099497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005889082,"threshold_uncertainty_score":0.002387524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04486322884055652,"score_gpt":0.3591612675960709,"score_spread":0.3142980387555143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}