{"id":"W4323349848","doi":"10.1016/j.jmb.2023.168041","title":"Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type II Anti-CRISPR Proteins","year":2023,"lang":"en","type":"review","venue":"Journal of Molecular Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Biology; Mobile genetic elements; Genome editing; Cas9; Computational biology; Trans-activating crRNA; Plasmid; CRISPR interference; Transposable element; Palindrome; Archaea; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004397417,0.000396359,0.001238436,0.0002673457,0.00005414339,0.00001029322,0.0003623281,0.0007308424,0.00002557513],"category_scores_gemma":[0.0002257712,0.000334447,0.0006797054,0.0002815708,0.00008419126,0.000003471818,0.0003163058,0.0003807916,0.00001073337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002942997,"about_ca_system_score_gemma":0.0002353419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007777106,"about_ca_topic_score_gemma":0.00000210757,"domain_scores_codex":[0.9979647,0.0001997812,0.000971419,0.0003513937,0.0001849733,0.0003277723],"domain_scores_gemma":[0.9983281,0.00001947378,0.0008660905,0.0003768585,0.0002857656,0.0001237427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003571353,0.0001252659,0.000001654695,0.002463581,0.0008403823,0.000101857,0.00001617502,0.00003968153,0.9226582,0.0002151404,0.003925385,0.06957698],"study_design_scores_gemma":[0.0005736093,0.002382472,0.000001255338,0.001991853,0.0007842887,0.000414426,0.0000392237,0.000003149822,0.3664435,0.0003527498,0.6265008,0.0005125791],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001752782,0.9071611,0.08976139,0.00002887407,0.0006929137,0.0004181864,0.0001279015,0.00001051361,0.00004633202],"genre_scores_gemma":[0.00476948,0.992601,0.001764515,0.00004677475,0.0002462163,0.0000125625,0.0003319262,0.00008998755,0.0001374886],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6225755,"threshold_uncertainty_score":0.9999108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02189250775914624,"score_gpt":0.3737601008046184,"score_spread":0.3518675930454722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}