{"id":"W4323350620","doi":"10.1093/jcag/gwac036.029","title":"A29 HIGH DIMENSIONAL SINGLE CELL ANALYSIS OF IL-4 TREATED MACROPHAGES REVEALS A HETEROGENIC PHENOTYPE AND THE ABSENCE OF CD206+ SUBSETS IN CROHN'S DISEASE PATIENTS","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Interleukin 4; FOXP3; Crohn's disease; Interleukin 10; Immunology; Population; Interleukin; Interleukin 17; Medicine; Inflammation; Disease; Cytokine; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303828,0.000109649,0.0002034221,0.0004528079,0.0001829269,0.000291397,0.00009929608,0.0002738603,0.002994979],"category_scores_gemma":[0.0001119243,0.00008038994,0.0001572543,0.0002176237,0.0001257768,0.00008629935,0.0001566391,0.0002306408,0.0007245574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007159112,"about_ca_system_score_gemma":0.00005129692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003415428,"about_ca_topic_score_gemma":0.0003124073,"domain_scores_codex":[0.9998982,0.00001664211,0.0000134426,0.00002660389,0.000022648,0.00002243203],"domain_scores_gemma":[0.9999288,0.00001481976,0.00001063044,0.00001052054,0.00001630434,0.0000189356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007845248,0.00004414362,0.01272605,0.00004324545,0.00001271208,0.0004837848,0.0001269248,0.00008437948,0.9821191,0.00005970923,0.0001268633,0.003388491],"study_design_scores_gemma":[0.0000818113,0.001541055,0.5074943,0.00004446943,0.000109408,0.006916081,0.0009417003,0.004301426,0.4694242,0.0003183546,0.00879737,0.00002978594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969156,0.0006149909,0.001224081,0.00003402233,0.00001369455,0.0000171032,0.0004971365,0.00002603984,0.0006573893],"genre_scores_gemma":[0.9952353,0.0002994715,0.001829401,0.00004866949,0.00001086591,0.00004936667,0.0009772816,0.00001184248,0.00153787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002994979,"threshold_uncertainty_score":0.01001924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003834172544174705,"score_gpt":0.1931577840293673,"score_spread":0.1893236114851926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}