{"id":"W4323350699","doi":"10.1093/jcag/gwac036.230","title":"A230 A MISSENSE MUTATION IN GOBLET CELL PROTEIN FCGBP ALTERS THE GLYCOMIC PROFILE AND FUNCTION OF THE COLONIC MUCUS BARRIER","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia; University of Calgary","funders":"","keywords":"Mucin; Mucus; Goblet cell; Mucin 2; Biology; Glycosylation; Cell biology; Missense mutation; Glycoprotein; Chemistry; Mutation; Molecular biology; Epithelium; Biochemistry; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001110222,0.0005855709,0.0003458956,0.0002519625,0.0002037137,0.0002376518,0.0002474555,0.0009162024,0.002260914],"category_scores_gemma":[0.00025644,0.0001359126,0.0006109031,0.0002469294,0.0004989602,0.0001365364,0.0002699268,0.0005895031,0.0004506976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003333023,"about_ca_system_score_gemma":0.0002473925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002549088,"about_ca_topic_score_gemma":0.001881252,"domain_scores_codex":[0.9998422,0.00002253966,0.0000160563,0.00004197416,0.00004685655,0.00003036229],"domain_scores_gemma":[0.9997746,0.00004795104,0.00007056586,0.00001489143,0.00001668627,0.0000752453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002643901,0.000056214,0.00120132,0.00004549883,0.00002704536,0.005578394,0.00004218747,0.000113725,0.9915481,0.0001143992,0.00008965299,0.0009189672],"study_design_scores_gemma":[0.000182765,0.002425251,0.08584324,0.00005527533,0.0002427969,0.03374157,0.0004682181,0.003191384,0.8657504,0.0003137659,0.007705427,0.00007980915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974582,0.0004811621,0.0007304462,0.0001245791,0.00006959873,0.00003367039,0.0004321327,0.00005975648,0.0006105796],"genre_scores_gemma":[0.9975367,0.0002180759,0.0006579231,0.0001019127,0.00001434636,0.00002006485,0.000230758,0.00002203295,0.001198196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002549088,"threshold_uncertainty_score":0.007563531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005606045999036221,"score_gpt":0.2163031283768194,"score_spread":0.2106970823777832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}