{"id":"W4323350746","doi":"10.1093/jcag/gwac036.003","title":"A3 CROHN’S DISEASE PROTEOLYTIC MICROBIOTA ENHANCES INFLAMMATION THROUGH PAR2 PATHWAY IN GNOTOBIOTIC MICE","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"","keywords":"Proteases; Biology; Colitis; Proteolytic enzymes; Inflammation; Microbiology; Inflammatory bowel disease; Immunology; Internal medicine; Biochemistry; Medicine; Disease; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002499464,0.0007343825,0.0005336956,0.0007236124,0.0002692724,0.0004779413,0.0002801765,0.0007242544,0.004856003],"category_scores_gemma":[0.0001555577,0.0003291803,0.0005505744,0.0002577856,0.0004928097,0.0004892491,0.00031701,0.001750562,0.001027608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003470755,"about_ca_system_score_gemma":0.0002631901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004005063,"about_ca_topic_score_gemma":0.00062115,"domain_scores_codex":[0.9996204,0.0000491063,0.00003569651,0.0001184869,0.00008135602,0.00009483025],"domain_scores_gemma":[0.9994949,0.00002466039,0.0001764641,0.00004592866,0.00003132265,0.0002266974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008253636,0.000139187,0.0002897777,0.00004618962,0.00000730235,0.00009892284,0.0000170277,0.00002608297,0.9977501,0.00006833417,0.00007708176,0.0006545972],"study_design_scores_gemma":[0.0004417044,0.005222788,0.03857233,0.00005119111,0.0001038392,0.002332697,0.0002631555,0.001532968,0.9453962,0.0002810832,0.005774022,0.00002819513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931925,0.0007700437,0.001921939,0.0004146127,0.00006764037,0.00005182291,0.001622805,0.0001991706,0.001759523],"genre_scores_gemma":[0.983224,0.0008292563,0.00474801,0.0004047983,0.00005667089,0.0001836788,0.00179308,0.0001074723,0.008652902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004856003,"threshold_uncertainty_score":0.01624489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005759435673728866,"score_gpt":0.2116218578197412,"score_spread":0.2058624221460123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}