{"id":"W4323350804","doi":"10.1093/jcag/gwac036.178","title":"A178 ELUCIDATING THE ROLE OF THE LEUCINE-RICH REPEAT KINASE 2 G2019S MUTATION IN CROHN’S DISEASE PATHOGENESIS USING A CITROBACTER RODENTIUM INFECTIOUS COLITIS MODEL","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Citrobacter rodentium; Immunology; Biology; Colitis; Pathogenesis; Pathogen; Citrobacter; LRRK2; Inflammation; Inflammatory bowel disease; Immune system; Spleen; Microbiology; Disease; Medicine; Pathology; Enterobacter; Parkinson's disease; Gene; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002249468,0.0006041296,0.0003212221,0.0004238937,0.0002538101,0.0002735753,0.0002706123,0.0006739856,0.001319236],"category_scores_gemma":[0.0001425214,0.0001975687,0.0004727212,0.0001611031,0.0003984478,0.0003014691,0.0002362583,0.0008662736,0.0002459475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004051128,"about_ca_system_score_gemma":0.0002177154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061567,"about_ca_topic_score_gemma":0.001205582,"domain_scores_codex":[0.9998046,0.00003614327,0.0000242619,0.00004996665,0.0000324133,0.00005263476],"domain_scores_gemma":[0.9997401,0.00002992959,0.00008591264,0.0000225859,0.00001593708,0.0001055175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008054807,0.0004353756,0.0009390322,0.00003828776,0.000009225467,0.0003033666,0.00002600655,0.0001148879,0.9962842,0.00007868728,0.00005828868,0.000907184],"study_design_scores_gemma":[0.0003254765,0.01763264,0.02906021,0.00003991087,0.00008198353,0.003298779,0.0003101394,0.004343191,0.9413401,0.0002176475,0.003312052,0.00003798333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976773,0.0003984434,0.0007888897,0.0001229395,0.00003026386,0.00007450525,0.0003613294,0.00004032448,0.0005061928],"genre_scores_gemma":[0.9957716,0.000355846,0.002059055,0.00008190594,0.000009201333,0.00008602468,0.0003621166,0.00001323401,0.001260864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001319236,"threshold_uncertainty_score":0.004413247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005589992566179952,"score_gpt":0.2105335751026638,"score_spread":0.2049435825364838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}