{"id":"W4323350984","doi":"10.1093/jcag/gwac036.174","title":"A174 A NOVEL MECHANISM OF CROHN’S DISEASE SEVERITY IN WOMEN: EVALUATING THE IMPACT OF AN ESTROGEN-FARNESOID X RECEPTOR INTERACTION ON INTESTINAL BARRIER FUNCTION","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Farnesoid X receptor; Intestinal permeability; Estrogen receptor; Estrogen; Internal medicine; Endocrinology; Nuclear receptor; Chenodeoxycholic acid; Bile acid; Barrier function; Receptor; Estrogen receptor alpha; Estrogen receptor beta; Transactivation; Chemistry; Biology; Cancer research; Transcription factor; Medicine; Cell biology; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004677305,0.0003823225,0.0004837974,0.0004339491,0.0002827225,0.0004926508,0.0001993074,0.0005071447,0.003120544],"category_scores_gemma":[0.0006715024,0.0002372391,0.0006058666,0.0003962056,0.0002349305,0.0002422869,0.0002484866,0.0004443429,0.0003969167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002127348,"about_ca_system_score_gemma":0.0002296402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008661518,"about_ca_topic_score_gemma":0.0007384729,"domain_scores_codex":[0.9997662,0.0000698037,0.00001459107,0.00007312728,0.00003767983,0.00003868343],"domain_scores_gemma":[0.9997532,0.00005430677,0.00008214181,0.00003116515,0.00002744825,0.00005184825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009296525,0.000548795,0.8491929,0.0003850944,0.0006615687,0.001368164,0.0003407557,0.0001747391,0.1148152,0.0002822023,0.0007579919,0.02217602],"study_design_scores_gemma":[0.0001013849,0.002392583,0.9844986,0.00004148157,0.0004961409,0.001914184,0.0003172882,0.0005397536,0.007415055,0.0002875185,0.00198093,0.00001498397],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952897,0.002534548,0.0007404342,0.0001765353,0.00003681844,0.00002752062,0.0005267484,0.00001514016,0.0006527278],"genre_scores_gemma":[0.9973214,0.0005777739,0.0004676895,0.0001270541,0.0000200563,0.00004209458,0.000314023,0.000007392469,0.001122421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003120544,"threshold_uncertainty_score":0.01043928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236412427067042,"score_gpt":0.2730069412952448,"score_spread":0.2606428170245744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}