{"id":"W4323350987","doi":"10.1093/jcag/gwac036.027","title":"A27 DNA HYPOMETHYLATION INDUCED BY 5-AZA-CDR OR LOSS OF DNMT1 INHIBITS COLITIS-ASSOCIATED COLORECTAL CANCER","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"DNA methylation; Colorectal cancer; Carcinogenesis; Colitis; Cancer research; Adenomatous polyposis coli; Epigenetics; Cancer; Ulcerative colitis; DNA methyltransferase; Methyltransferase; Methylation; Inflammatory bowel disease; DNMT1; Medicine; Biology; Molecular biology; Gene expression; Immunology; Internal medicine; DNA; Gene; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001531829,0.0002735427,0.0004860503,0.0005314035,0.0001852065,0.0002763599,0.0002362344,0.0002096977,0.003456492],"category_scores_gemma":[0.0001370584,0.0001634505,0.0004304894,0.000416481,0.0001691004,0.0001144172,0.0001953012,0.0007518711,0.0007448529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004266894,"about_ca_system_score_gemma":0.0004574696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002667264,"about_ca_topic_score_gemma":0.004566036,"domain_scores_codex":[0.9998114,0.00001643349,0.00001738529,0.00005885305,0.00004807451,0.00004799938],"domain_scores_gemma":[0.9998837,0.00001557551,0.00003187762,0.00001593718,0.00001340616,0.000039647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007988231,0.0001432962,0.001057453,0.0001738095,0.00006196404,0.00002104691,0.00001286105,0.0003181547,0.9917922,0.00006111226,0.0009170521,0.00464238],"study_design_scores_gemma":[0.000173979,0.002176678,0.02559183,0.00002710743,0.0001569491,0.0001721451,0.00006345414,0.002325852,0.9557026,0.00009744878,0.01349619,0.00001577936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777015,0.005099507,0.002115918,0.0002820554,0.0001326681,0.00007679615,0.01072701,0.0006699382,0.003194664],"genre_scores_gemma":[0.9837038,0.002250551,0.001777843,0.0001254495,0.00001771524,0.0001242978,0.00890024,0.00005865991,0.003041433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003456492,"threshold_uncertainty_score":0.01156318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163999363887274,"score_gpt":0.2505723432415599,"score_spread":0.2389323496026871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}