{"id":"W4323351010","doi":"10.1093/jcag/gwac036.277","title":"A277 A NOVEL PH-SENSITIVE Μ-OPIOID RECEPTOR AGONIST THAT DOES NOT INDUCE TOLERANCE IN A COLITIS MOUSE MODEL","year":2023,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Agonist; DAMGO; Opioid; Pharmacology; Analgesic; Fentanyl; Colitis; Visceral pain; Tachyphylaxis; Anesthesia; Dorsal root ganglion; Drug tolerance; Opioid receptor; Internal medicine; Nociception; Receptor; Spinal cord","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872692,0.000549886,0.0006591022,0.0005444836,0.000236423,0.0002832956,0.000563104,0.0007893776,0.003187086],"category_scores_gemma":[0.0001304941,0.0002597829,0.0005918513,0.0002630662,0.0003293316,0.0004385948,0.0001737705,0.001402717,0.0009539357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002291726,"about_ca_system_score_gemma":0.0003666649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005309332,"about_ca_topic_score_gemma":0.0008324466,"domain_scores_codex":[0.9997421,0.00003479322,0.00002867616,0.00005489032,0.00007088055,0.00006853946],"domain_scores_gemma":[0.9998336,0.00001399386,0.00003894293,0.00002186111,0.00002098313,0.00007054471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001295474,0.0008105498,0.0001854189,0.0001592351,0.00003058287,0.000176964,0.00001741925,0.00008564974,0.9921807,0.0001526639,0.0004350499,0.004470219],"study_design_scores_gemma":[0.0008737092,0.02445563,0.005258368,0.00008503132,0.0001562535,0.001952896,0.0001287339,0.001912147,0.9524782,0.0002086026,0.01245568,0.00003467967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848425,0.003255508,0.004174155,0.0005463309,0.00021031,0.0002270604,0.001508501,0.0003388844,0.004896707],"genre_scores_gemma":[0.975409,0.003999342,0.005170949,0.0006712276,0.00006062461,0.0005146486,0.00241839,0.00007045298,0.01168543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003187086,"threshold_uncertainty_score":0.0106619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623672278551068,"score_gpt":0.237757117990964,"score_spread":0.2115203952054533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}